Grafting of PEO to Glass, Nitinol, and Pyrolytic Carbon Surfaces by Gamma Irradiation

Glass, nitinol, and pyrolytic carbon surfaces were grafted with poly (ethylene oxide) (PEO) and PEO-containing Pluronic surfactants by gamma irradiation. These substrates were coated with a primer layer of trichlorovinylsilane (TCVS), which allows grafting of organic polymers. The TCVS-coated substrates were adsorbed with PEO or Pluronics and exposed to 0.3 Mrad of gamma radiation to graft the polymer to the surface. PEO-grafted substrates were characterized by contact angle measurement, X-ray photoelectron spectroscopy, fibrinogen adsorption, and platelet adhesion and activation. Surface modification with PEO reduced fibrinogen adsorption by as much as 99%. Platelet adhesion was significnatly reduced or prevented on the modified surfaces. Protein- and platelet-resistance effects were independent of hydrophilicity of the PEO-grafted surfaces. Polymer grafting by gamma radiation to TCVS-coated substrates provides a facile process to improve thromboresistance of inorganic biomaterials.