Chicken Dystrophy. The Geometry of the Transverse Tubules

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1976 Aug 1

PMID 941980

Citations 16

Authors

N N Malouf

J R SOMMER

Affiliations

Soon will be listed here.

Abstract

The pectoral muscle of chickens afflicted with muscular dystrophy, when examined with the electron microscope, contains a) numerous, often quite large vesicles with and without caveolar evaginations, b) tubules with caveolar evaginations, and c) tubular networks. We have demonstrated that all these structures are derivatives of the transverse tubles as revealed by tracer studies and freeze-fracture complementary replicas. The membranes of transverse tubular origin show a small number of intramembranous particles on both P and E faces with no complementary geometry. The membranes of the free sacrcoplasmic reticulum (SR) and the junctional SR of normal and dystrophic muscle appear identical in complementary freeze-fracture replicas. Vesicles that carry only a small number of particles on both E and P faces exposed by freeze-fracturing in isolated SR preparations can be taken as presumptive evidence and serve as a morphologic marker for transverse tubular origin of such vesicles when mitochondrial and lysosomal contamination has been excluded.

Citing Articles

Persistent tubular conduction in vacuolated amphibian skeletal muscle following osmotic shock.

Devlin C, Chawl S, Skepper J, Huan C J Muscle Res Cell Motil. 2002; 22(5):459-66.

PMID: 11964071 DOI: 10.1023/a:1014502302031.

Loop diuretics inhibit detubulation and vacuolation in amphibian muscle fibres exposed to osmotic shock.

Khan K, Skepper J, Hockaday A, Burgess A, Huang C J Muscle Res Cell Motil. 2000; 21(1):79-90.

PMID: 10813637 DOI: 10.1023/a:1005618720122.

Cardiac glycosides inhibit detubulation in amphibian skeletal muscle fibres exposed to osmotic shock.

Nik-Zainal S, Skepper J, Hockaday A, Huang C J Muscle Res Cell Motil. 1999; 20(1):45-53.

PMID: 10360233 DOI: 10.1023/a:1005494114976.

Intracytoplasmic vacuoles in alpha W fibers of dystrophic chicken muscle--probable early pathologic event initiates massive fiber necrosis.

Nonaka I, Sugita H Acta Neuropathol. 1981; 55(3):173-81.

PMID: 7349576 DOI: 10.1007/BF00691315.

Freeze-fracture studies of muscle caveolae in human muscular dystrophy.

Bonilla E, Fischbeck K, SCHOTLAND D Am J Pathol. 1981; 104(2):167-73.

PMID: 7258302 PMC: 1903751.

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