Induction of Matrix Metalloproteinases Following Brain Injury in Rats

Overview

Journal Acta Neurochir Suppl

Specialty Neurosurgery

Date 1997 Jan 1

PMID 9416327

Citations 4

Authors

M Shibayama

H Kuchiwaki

S Inao

K Ichimi

J Yoshida

M Hamaguchi

Affiliations

Soon will be listed here.

Abstract

Matrix metalloproteinases (MMPs) are important in various pathophysiological processes related with the tissue remodeling. We planned the experiments to determine whether MMPs participate in disruption and repair of the tissue following brain injury. We have studied induction of MMP-9, a 92 kilodalton (kDa) gelatinase, in traumatic brain tissue, which may be produced by brain residual cells. We speculate that MMP-9 plays a role in post-traumatic brain edema formation.

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