Investigations on the Frequency of Chromosome Aberrations in Bone Marrow Cells of Chinese Hamsters After Simultaneous Application of Caffeine and Cyclophosphamide

Overview

Journal Hum Genet

Specialty Genetics

Date 1976 Jul 27

PMID 939563

Authors

G ROHRBORN

U Buckel

Affiliations

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Abstract

The potentiating effect of caffeine (1,3,7-trimethylxanthine) on chemically induced chromosome aberrations was studied in bone marrow cells of chinese hamsters, exposed to the alkylating agent cyclophosphamide. Four experimental series were performed: In the first two tests caffeine (200 mg/kg) or cyclophosphamide (40 mg/kg), respectively, were administered. A third and fourth test was performed with caffeine plus cyclophosphamide (200 + 40 mg/kg and 35 + 40 mg/kg, respectively) simultaneously. Aberrations induced by cyclophosphamide (40 mg/kg) were strongly potentiated by simultaneous application of caffeine (200 mg/kg) not only additively but even synergistically. This increase of aberrations cannot be found after injection of the lower dose of caffeine (35 mg/kg).

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