Characterization of Lipoprotein IRP1 from Corynebacterium Diphtheriae, Which is Regulated by the Diphtheria Toxin Repressor (DtxR) and Iron

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1997 Dec 11

PMID 9393842

Citations 22

Authors

M P Schmitt

B G Talley

R K Holmes

Affiliations

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Abstract

The Corynebacterium diphtheriae irp1 gene is negatively regulated by DtxR and iron. The nucleotide sequence of irp1 revealed that it has homology with genes involved in iron acquisition. Expression of the irp1 gene showed that it encodes a lipoprotein (IRP1) with a predicted size of 38 kDa. Northern blot experiments indicated that transcription from the irp1 promoter is repressed in high-iron medium and suggested that irp1 is part of an iron-regulated operon.

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