Regional Serotonin Levels in Brain: a Comparison of Depressive Suicides and Alcoholic Suicides with Controls

Overview

Journal Biol Psychiatry

Publisher Elsevier

Specialty Psychiatry

Date 1976 Jun 1

PMID 938697

Citations 11

Authors

E Cochran

E Robins

S Grote

Affiliations

Soon will be listed here.

Abstract

The levels of 5-hydroxytryptamine have been measured in 33 areas of the human brain and these levels compared in depressed suicides, in alcoholic suicides, and in controls. The values obtained for control brains ranged from 5.3 mumole 5-HT/kg wet weight in substantia nigra to 0.4 mumole 5-HT/kg wet weight in frontal gray. No significant differences were found among diagnostic groups in any of the areas studied.

Citing Articles

Elevated serotonin and 5-HIAA in the brainstem and lower serotonin turnover in the prefrontal cortex of suicides.

Bach H, Huang Y, Underwood M, Dwork A, Mann J, Arango V Synapse. 2013; 68(3):127-30.

PMID: 23813499 PMC: 3872491. DOI: 10.1002/syn.21695.

Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity.

Stockmeier C, Shapiro L, Dilley G, Kolli T, Friedman L, Rajkowska G J Neurosci. 1998; 18(18):7394-401.

PMID: 9736659 PMC: 6793229.

Brain monoaminergic and neuropeptidergic variations in human aging.

Arranz B, Blennow K, Ekman R, Eriksson A, Mansson J, Marcusson J J Neural Transm (Vienna). 1996; 103(1-2):101-15.

PMID: 9026365 DOI: 10.1007/BF01292620.

Lower 3H-paroxetine binding in cerebral cortex of suicide victims is partly due to fewer high affinity, non-transporter sites.

Mann J, Henteleff R, Lagattuta T, Perper J, Li S, Arango V J Neural Transm (Vienna). 1996; 103(11):1337-50.

PMID: 9013420 DOI: 10.1007/BF01271194.

Effect of aging on lazabemide binding, monoamine oxidase activity and monoamine metabolites in human frontal cortex.

Galva M, Bondiolotti G, Olasmaa M, Picotti G J Neural Transm Gen Sect. 1995; 101(1-3):83-94.

PMID: 8695059 DOI: 10.1007/BF01271547.