Histocompatibility Typing in Amyotrophic Lateral Sclerosis

Overview

Journal Arch Neurol

Specialty Neurology

Date 1976 Jun 1

PMID 938267

Citations 7

Authors

J P Antel

B G Arnason

T C Fuller

J R Lehrich

Affiliations

Soon will be listed here.

Abstract

Histocompatibility (HL-A) phenotypes of 44 unrelated white patients from the greater Boston area with amyotrophic lateral sclerosis (ALS) and 200 white controls were compared. In the overall ALS group, an increased frequency of HL-A3 was noted (43% vs 25%, P less than .05). Thirty-eight patients had rapidly progressive disease; among this group the HL-A3 incidence was 50% (P less than .005). Six patients had slowly progressive disease, none had HL-A3, and five had HL-A12. The HL-A antigens may link with disease severity in ALS.

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