Vitamin D Receptors and Anti-proliferative Effects of Vitamin D Derivatives in Human Pancreatic Carcinoma Cells in Vivo and in Vitro

Overview

Journal Br J Cancer

Specialty Oncology

Date 1997 Jan 1

PMID 9376260

Citations 42

Authors

K W Colston

S Y James

L Binderup

A G Grant

Affiliations

Soon will be listed here.

Abstract

The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 microg kg(-1) body weight i.p. thrice weekly for 4-6 weeks. Tumour growth was significantly inhibited in treated animals compared with controls in the absence of hypercalcaemia. These findings may have therapeutic implications in pancreatic cancer.

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