Structural Studies of Natural Product Biosynthetic Proteins

Overview

Journal Chem Biol

Publisher Elsevier

Specialties Biochemistry
Biology
Chemistry

Date 1997 Dec 31

PMID 9375250

Citations 6

Authors

C A Townsend

Affiliations

Soon will be listed here.

Abstract

The first high-resolution structures of key proteins involved in the biosynthesis of several natural product classes are now appearing. In some cases, they have resulted in a significantly improved mechanistic understanding of the often complex processes catalyzed by these enzymes, and they have also opened the way for more rational efforts to modify the products made.

Citing Articles

CusProSe: a customizable protein annotation software with an application to the prediction of fungal secondary metabolism genes.

Oliveira L, Chevrollier N, Dallery J, OConnell R, Lebrun M, Viaud M Sci Rep. 2023; 13(1):1417.

PMID: 36697464 PMC: 9876896. DOI: 10.1038/s41598-023-27813-y.

Organocatalytic cascade reactions as a new tool in total synthesis.

Grondal C, Jeanty M, Enders D Nat Chem. 2010; 2(3):167-78.

PMID: 21124474 DOI: 10.1038/nchem.539.

SMURF: Genomic mapping of fungal secondary metabolite clusters.

Khaldi N, Seifuddin F, Turner G, Haft D, Nierman W, Wolfe K Fungal Genet Biol. 2010; 47(9):736-41.

PMID: 20554054 PMC: 2916752. DOI: 10.1016/j.fgb.2010.06.003.

The structure of ActVA-Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis.

Sciara G, Kendrew S, Miele A, Marsh N, Federici L, Malatesta F EMBO J. 2003; 22(2):205-15.

PMID: 12514126 PMC: 140106. DOI: 10.1093/emboj/cdg031.

A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.

Udwary D, Merski M, Townsend C J Mol Biol. 2002; 323(3):585-98.

PMID: 12381311 PMC: 3400148. DOI: 10.1016/s0022-2836(02)00972-5.