Expression of the Neonatal Fc Receptor, FcRn, on Human Intestinal Epithelial Cells

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1997 Nov 26

PMID 9370926

Citations 128

Authors

E J Israel

S Taylor

Z Wu

E Mizoguchi

R S Blumberg

A Bhan

N E Simister

Affiliations

Soon will be listed here.

Abstract

Maternal IgG is transferred to the suckling mouse and rat through a major histocompatibility complex (MHC) class I-related Fc receptor (FcRn) on the brush border of the proximal small intestine. We have previously described a site on the epithelial surface of the human fetal intestine with IgG binding characteristics similar to FcRn. We report here the identification by reverse transcriptase polymerase chain reaction amplification and sequencing of the human orthologue of rat and mouse FcRn in tissue obtained from human fetal and adult intestine. FcRn protein was detected in adult human intestine by western blot. Immunohistochemical studies of sections of human intestine show that the FcRn is localized mostly to the epithelial cells, where it is in the apical region. These data suggest that the binding of IgG previously seen in the fetal intestine is due to the presence of FcRn. Potential roles for this MHC class I-like Fc receptor in the human intestine include the transfer of passive immunity, induction of oral tolerance, and immunosurveillance.

Citing Articles

Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge.

Coates M, Richoz N, Tuong Z, Bowyer G, Lee C, Ferdinand J Nat Immunol. 2025; 26(2):215-229.

PMID: 39890933 PMC: 11785532. DOI: 10.1038/s41590-024-02064-9.

Circulating extracellular vesicles in sera of chronic patients as a method for determining active parasitism in Chagas disease.

Lozano N, Prescilla-Ledezma A, Calabuig E, Trelis M, Arce J, Lopez Hontangas J PLoS Negl Trop Dis. 2024; 18(11):e0012356.

PMID: 39565824 PMC: 11616892. DOI: 10.1371/journal.pntd.0012356.

Antibodies in breast milk: Pro-bodies designed for healthy newborn development.

Verhasselt V, Tellier J, Carsetti R, Tepekule B Immunol Rev. 2024; 328(1):192-204.

PMID: 39435770 PMC: 11659933. DOI: 10.1111/imr.13411.

IgE versus IgG and IgA: Differential roles of allergen-specific antibodies in sensitization, tolerization, and treatment of allergies.

Knol E, van Neerven R Immunol Rev. 2024; 328(1):314-333.

PMID: 39285523 PMC: 11659938. DOI: 10.1111/imr.13386.

COVID-19 booster enhances IgG mediated viral neutralization by human milk .

Valcarce V, Stafford L, Neu J, Parker L, Vicuna V, Cross T Front Nutr. 2024; 11:1289413.

PMID: 38406184 PMC: 10884187. DOI: 10.3389/fnut.2024.1289413.

References

Israel E, Patel V, Taylor S, Marshak-Rothstein A, Simister N . Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J Immunol. 1995; 154(12):6246-51. View

Roos N, Mahe S, Benamouzig R, SICK H, Rautureau J, Tome D . 15N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J Nutr. 1995; 125(5):1238-44. DOI: 10.1093/jn/125.5.1238. View

Junghans R, Anderson C . The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor. Proc Natl Acad Sci U S A. 1996; 93(11):5512-6. PMC: 39277. DOI: 10.1073/pnas.93.11.5512. View

Simister N, Story C, Chen H, Hunt J . An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human placenta. Eur J Immunol. 1996; 26(7):1527-31. DOI: 10.1002/eji.1830260718. View

Israel E, Wilsker D, Hayes K, Schoenfeld D, Simister N . Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn. Immunology. 1996; 89(4):573-8. PMC: 1456584. DOI: 10.1046/j.1365-2567.1996.d01-775.x. View

Brambell F, HEMMINGS W, Morris I . A THEORETICAL MODEL OF GAMMA-GLOBULIN CATABOLISM. Nature. 1964; 203:1352-4. DOI: 10.1038/2031352a0. View

Hobbs J, Davis J . Serum gamma-G-globulin levels and gestational age in premature babies. Lancet. 1967; 1(7493):757-9. DOI: 10.1016/s0140-6736(67)91369-4. View

Abrahamson D, Powers A, Rodewald R . Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young. Science. 1979; 206(4418):567-9. DOI: 10.1126/science.493961. View

Chirgwin J, Przybyla A, MacDonald R, Rutter W . Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 1979; 18(24):5294-9. DOI: 10.1021/bi00591a005. View

10.

Blum P, Phelps D, Ank B, Krantman H, Stiehm E . Survival of oral human immune serum globulin in the gastrointestinal tract of low birth weight infants. Pediatr Res. 1981; 15(9):1256-60. DOI: 10.1203/00006450-198109000-00006. View

11.

Barnes G, Doyle L, Hewson P, Knoches A, McLellan J, KITCHEN W . A randomised trial of oral gammaglobulin in low-birth-weight infants infected with rotavirus. Lancet. 1982; 1(8286):1371-3. DOI: 10.1016/s0140-6736(82)92496-5. View

12.

Peppard J, Jackson L, Hall J, Robertson D . The transfer of immune complexes from the lumen of the small intestine to the bloodstream in sucking rats. Immunology. 1984; 53(2):385-93. PMC: 1454826. View

13.

Ballow M, Cates K, Rowe J, Goetz C, Desbonnet C . Development of the immune system in very low birth weight (less than 1500 g) premature infants: concentrations of plasma immunoglobulins and patterns of infections. Pediatr Res. 1986; 20(9):899-904. DOI: 10.1203/00006450-198609000-00019. View

14.

Besser T, McGuire T, Gay C, Pritchett L . Transfer of functional immunoglobulin G (IgG) antibody into the gastrointestinal tract accounts for IgG clearance in calves. J Virol. 1988; 62(7):2234-7. PMC: 253360. DOI: 10.1128/JVI.62.7.2234-2237.1988. View

15.

Eibl M, Wolf H, Furnkranz H, Rosenkranz A . Prevention of necrotizing enterocolitis in low-birth-weight infants by IgA-IgG feeding. N Engl J Med. 1988; 319(1):1-7. DOI: 10.1056/NEJM198807073190101. View

16.

Simister N, Mostov K . An Fc receptor structurally related to MHC class I antigens. Nature. 1989; 337(6203):184-7. DOI: 10.1038/337184a0. View

17.

Kobayashi K, Blaser M, Brown W . Identification of a unique IgG Fc binding site in human intestinal epithelium. J Immunol. 1989; 143(8):2567-74. View

18.

Roberts D, Guenthert M, Rodewald R . Isolation and characterization of the Fc receptor from the fetal yolk sac of the rat. J Cell Biol. 1990; 111(5 Pt 1):1867-76. PMC: 2116321. DOI: 10.1083/jcb.111.5.1867. View

19.

Melamed I, Griffiths A, Roifman C . Benefit of oral immune globulin therapy in patients with immunodeficiency and chronic diarrhea. J Pediatr. 1991; 119(3):486-9. DOI: 10.1016/s0022-3476(05)82070-0. View

20.

Rubaltelli F, Benini F, Sala M . Prevention of necrotizing enterocolitis in neonates at risk by oral administration of monomeric IgG. Dev Pharmacol Ther. 1991; 17(3-4):138-43. DOI: 10.1159/000457513. View