General Mechanisms of Metastasis

Overview

Journal Cancer

Publisher Wiley

Specialty Oncology

Date 1997 Nov 15

PMID 9362419

Citations 200

Authors

E C Woodhouse

R F Chuaqui

L A Liotta

Affiliations

Soon will be listed here.

Abstract

In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti-metastasis therapies are being developed.

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