The Ubiquitin System

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1997 Nov 14

PMID 9357313

Citations 173

Authors

A Varshavsky

Affiliations

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Abstract

Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.

Citing Articles

Histone H2B ubiquitylation: Connections to transcription and effects on chromatin structure.

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Unique E2-binding specificity of artificial RING fingers in cancer cells.

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The silencing of NREP aggravates OA cartilage damage through the TGF-β1/Smad2/3 pathway in chondrocytes.

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A Ubiquitin-Based Module Directing Protein-Protein Interactions in Chloroplasts.

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Molecular basis for C-degron recognition by CRL2 ubiquitin ligase.

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