Rapid Evolution of a Young L1 (LINE-1) Clade in Recently Speciated Rattus Taxa

Overview

Journal J Mol Evol

Specialty Biochemistry

Date 1997 Oct 8

PMID 9321420

Citations 15

Authors

E L Cabot

B Angeletti

K Usdin

A V Furano

Affiliations

Soon will be listed here.

Abstract

L1 elements are retrotransposons that have been replicating and evolving in mammalian genomes since before the mammalian radiation. Rattus norvegicus shares the young L1mlvi2 clade only with its sister taxon, Rattus cf moluccarius. Here we compared the L1mlvi2 clade in these recently diverged species and found that it evolved rapidly into closely related but distinct clades: the L1mlvi2-rm clade (or subfamily), characterized here from R. cf moluccarius, and the L1mlvi2-rn clade, originally described in R. norvegicus. In addition to other differences, these clades are distinguished by a cluster of amino acid replacement substitutions in ORF I. Both rat species contain the L1mlvi2-rm clade, but the L1mlvi2-rn clade is restricted to R. norvegicus. Therefore, the L1mlvi2-rm clade arose prior to the divergence of R. norvegicus and R. cf moluccarius, and the L1mlvi2-rn clade amplified after their divergence. The total number of L1mlvi2-rm elements in R. cf moluccarius is about the same as the sum of the L1mlvi2-rm and L1mlvi2-rn elements in R. norvegicus. The possibility that L1 amplification is in some way limited so that the two clades compete for replicative supremacy as well as the implications of the other distinguishing characteristic of the L1mlvi2-rn and L1mlvi2-rm clades are discussed.

Citing Articles

SCIFER: approach for analysis of LINE-1 mRNA expression in single cells at a single locus resolution.

Stow E, Baddoo M, LaRosa A, LaCoste D, Deininger P, Belancio V Mob DNA. 2022; 13(1):21.

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Subfamily-specific differential contribution of individual monomers and the tether sequence to mouse L1 promoter activity.

Kong L, Saha K, Hu Y, Tschetter J, Habben C, Whitmore L Mob DNA. 2022; 13(1):13.

PMID: 35443687 PMC: 9022269. DOI: 10.1186/s13100-022-00269-z.

Organ-, sex- and age-dependent patterns of endogenous L1 mRNA expression at a single locus resolution.

Stow E, Kaul T, deHaro D, Dem M, Beletsky A, Morales M Nucleic Acids Res. 2021; 49(10):5813-5831.

PMID: 34023901 PMC: 8191783. DOI: 10.1093/nar/gkab369.

Cryptic genetic variation enhances primate L1 retrotransposon survival by enlarging the functional coiled coil sequence space of ORF1p.

Furano A, Jones C, Periwal V, Callahan K, Walser J, Cook P PLoS Genet. 2020; 16(8):e1008991.

PMID: 32797042 PMC: 7449397. DOI: 10.1371/journal.pgen.1008991.

Contrasted patterns of evolution of the LINE-1 retrotransposon in perissodactyls: the history of a LINE-1 extinction.

Sookdeo A, Hepp C, Boissinot S Mob DNA. 2018; 9:12.

PMID: 29610583 PMC: 5872511. DOI: 10.1186/s13100-018-0117-4.

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