Intrafamilial Correlation Analysis for IgM Serum Levels

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1977 Nov 1

PMID 930923

Citations 2

Authors

I Rostenberg

P E Suarez

S ARMENDARES

Affiliations

Soon will be listed here.

Abstract

The IgM serum level was determined in the members of 29 healthy families. The IgM mean concentrations between fathers and mothers and between sons and daughters were significantly different (P less than .01), with higher serum IgM levels in females than in males. Simple linear regression analysis was done for the following intrafamilial combinations: son-father, daughter-father, son-mother, and daughter-mother. Significant correlation coefficients (P less than .05) were obtained in all four combinations, which does not support the X-linked gene hypothesis (i.e., that the X chromosome carries quantitative genes for immunoglobulin M). An alternative explanation for the differences between sexes for IgM serum concentration is considered.

Citing Articles

Directional dominance for low IgM and IgA levels.

Clark P, Jardine R, Jones P, Martin N, Walsh R Am J Hum Genet. 1981; 33(5):709-21.

PMID: 7197465 PMC: 1685124.

A lod score method for detecting linkage on the X chromosone between a marker locus and a major gene locus for a quantitative.

Bock R, Perline R Behav Genet. 1979; 9(3):139-49.

PMID: 291432 DOI: 10.1007/BF01071297.

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