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Synergy Between the Genes for Butyrylcholinesterase K Variant and Apolipoprotein E4 in Late-onset Confirmed Alzheimer's Disease

Overview
Journal Hum Mol Genet
Specialties Genetics
Molecular Biology
Date 1997 Sep 25
PMID 9302273
Citations 34
Authors
D J Lehmann
C Johnston
A D Smith
Affiliations
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Abstract

The allelic frequency of the gene for the K variant of butyrylcholinesterase (BCHE-K) was 0.17 in 74 subjects with late-onset (age > 65 years) histopathologically diagnosed Alzheimer's disease (AD), which was higher than the frequencies in 104 elderly control subjects (0.09), in 14 early-onset cases of confirmed AD (0.07) and in 29 confirmed cases of other dementia (0.10). The association of BCHE-K with late-onset AD was limited to carriers of the epsilon 4 allele of the apolipoprotein E gene (APOE), among whom the presence of BCHE-K gave an odds ratio of confirmed late-onset AD of 6.9 (95% C.I. 1.65-29) in subjects > 65 years and of 12.8 (1.9-86) in subjects > 75 years. In APOE epsilon 4 carriers over 75 years, only 1/22 controls, compared with 10/24 confirmed late-onset AD cases, had BCHE-K. We suggest that BCHE-K, or a nearby gene on chromosome 3, acts in synergy with APOE epsilon 4 as a susceptibility gene for late-onset AD.

Citing Articles

Confirmed Synergy Between the ɛ4 Allele of Apolipoprotein E and the Variant K of Butyrylcholinesterase as a Risk Factor for Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Ratis R, Dacoregio M, Simao-Silva D, Mateus R, Machado L, Bonini J J Alzheimers Dis Rep. 2023; 7(1):613-625.

PMID: 37483326 PMC: 10357125. DOI: 10.3233/ADR-220084.

Interaction between Apolipoprotein E and Butyrylcholinesterase Genes on Risk of Alzheimer's Disease in a Prospective Cohort Study.

Chuang Y, Varma V, An Y, Tanaka T, Davatzikos C, Resnick S J Alzheimers Dis. 2020; 75(2):417-427.

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Butyrylcholinesterase Protein Ends in the Pathogenesis of Alzheimer's Disease-Could Genotyping Be Helpful in Alzheimer's Therapy?.

Jasiecki J, Wasag B Biomolecules. 2019; 9(10).

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Homomeric and Heteromeric Aβ Species Exist in Human Brain and CSF Regardless of Alzheimer's Disease Status and Risk Genotype.

Lana E, Gellerbring A, Jung S, Nordberg A, Unger Lithner C, Darreh-Shori T Front Mol Neurosci. 2019; 12:176.

PMID: 31417354 PMC: 6684963. DOI: 10.3389/fnmol.2019.00176.

Synergy between the alteration in the N-terminal region of butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease.

Jasiecki J, Limon-Sztencel A, Zuk M, Chmara M, Cysewski D, Limon J Sci Rep. 2019; 9(1):5223.

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