Effect of Aqueous Extract of Commiphora Opobalsamum on Blood Pressure and Heart Rate in Rats

Overview

Journal J Ethnopharmacol

Date 1997 Aug 1

PMID 9292417

Citations 9

Authors

A S Abdul-Ghani

R Amin

Affiliations

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Abstract

The cardiovascular effects of aqueous extracts from the branches of Commiphora opobalsamum tree were investigated. The intravenous administration of 4 mg/kg of the aqueous extract depressed systemic arterial blood pressure by 20% (P < 0.01) and reduced heart rate of anaesthetised rats by 14% (P < 0.05). The hypotensive and the bradycardiac effects were immediate and in a dose related manner. The hypotensive effect of C. opobalsamum was inhibited by the pretreatment with atropine sulfate (1-4 mg/kg). These results suggest that the hypotensive effect of C. opobalsamum is due to the activation of muscarinic cholinergic receptors.

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