Effectiveness of Hyaluronan on Corneal Epithelial Barrier Function in Dry Eye

Overview

Journal Br J Ophthalmol

Specialty Ophthalmology

Date 1997 Jul 1

PMID 9290362

Citations 28

Authors

N Yokoi

A Komuro

K Nishida

S Kinoshita

Affiliations

Soon will be listed here.

Abstract

Aims/background: The aim of this study was to assess quantitatively the effectiveness of hyaluronan on corneal disruption in patients with dry eye. Corneal epithelial barrier function was evaluated by measuring fluorescein permeability using a slit-lamp fluorophotometer.

Methods: 11 patients with dry eye were assigned to this study. Hyaluronan ophthalmic solution (0.1% hyaluronic acid) was instilled five times a day to the right eye, in addition to the usual artificial tear solutions. The left eye received only the artificial tear solutions. Corneal barrier function was evaluated on the pretreatment day, and at 2 and 4 weeks after treatment. Fluorophotometry was used to measure fluorescein uptake at the central and lower corneal portions.

Results: Two weeks after treatment, hyaluronan treated right corneas showed significant corneal epithelial barrier improvement in the lower portion, compared with the pretreatment day (p < 0.025). Four weeks after treatment, the treated corneas showed significant improvement in the central corneal portion (p < 0.025) and improvement in the lower portion, compared with the pretreatment day. The untreated left corneas, on the other hand showed no improvement during the course of the study.

Conclusion: This study suggests that hyaluronan is effective in the treatment of corneal epithelial disruption in dry eye.

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References

van Bijsterveld O . Diagnostic tests in the Sicca syndrome. Arch Ophthalmol. 1969; 82(1):10-4. DOI: 10.1001/archopht.1969.00990020012003. View

Shimmura S, Ono M, Shinozaki K, Toda I, Takamura E, Mashima Y . Sodium hyaluronate eyedrops in the treatment of dry eyes. Br J Ophthalmol. 1995; 79(11):1007-11. PMC: 505317. DOI: 10.1136/bjo.79.11.1007. View

Lemp M . Artificial tear solutions. Int Ophthalmol Clin. 1973; 13(1):221-9. DOI: 10.1097/00004397-197301310-00016. View

Lamberts D, Langston D, Chu W . A clinical study of slow-releasing artificial tears. Ophthalmology. 1978; 85(8):794-800. DOI: 10.1016/s0161-6420(78)35610-4. View

Graue E, POLACK F, Balazs E . The protective effect of Na-hyaluronate to corneal endothelium. Exp Eye Res. 1980; 31(1):119-27. DOI: 10.1016/0014-4835(80)90094-9. View

Fox R, Robinson C, Curd J, Kozin F, Howell F . Sjögren's syndrome. Proposed criteria for classification. Arthritis Rheum. 1986; 29(5):577-85. DOI: 10.1002/art.1780290501. View

Mengher L, Pandher K, Bron A, Davey C . Effect of sodium hyaluronate (0.1%) on break-up time (NIBUT) in patients with dry eyes. Br J Ophthalmol. 1986; 70(6):442-7. PMC: 1041038. DOI: 10.1136/bjo.70.6.442. View

Limberg M, McCAA C, Kissling G, Kaufman H . Topical application of hyaluronic acid and chondroitin sulfate in the treatment of dry eyes. Am J Ophthalmol. 1987; 103(2):194-7. DOI: 10.1016/s0002-9394(14)74226-6. View

Wysenbeek Y, Loya N, Ben Sira I, Ophir I, Ben Shaul Y . The effect of sodium hyaluronate on the corneal epithelium. An ultrastructural study. Invest Ophthalmol Vis Sci. 1988; 29(2):194-9. View

10.

Nelson J, Farris R . Sodium hyaluronate and polyvinyl alcohol artificial tear preparations. A comparison in patients with keratoconjunctivitis sicca. Arch Ophthalmol. 1988; 106(4):484-7. DOI: 10.1001/archopht.1988.01060130530029. View

11.

Sand B, Marner K, NORN M . Sodium hyaluronate in the treatment of keratoconjunctivitis sicca. A double masked clinical trial. Acta Ophthalmol (Copenh). 1989; 67(2):181-3. DOI: 10.1111/j.1755-3768.1989.tb00750.x. View

12.

Gurny R, Ryser J, Tabatabay C, Martenet M, EDMAN P, Camber O . Precorneal residence time in humans of sodium hyaluronate as measured by gamma scintigraphy. Graefes Arch Clin Exp Ophthalmol. 1990; 228(6):510-2. DOI: 10.1007/BF00918481. View

13.

Nishida T, Nakamura M, Mishima H, Otori T . Hyaluronan stimulates corneal epithelial migration. Exp Eye Res. 1991; 53(6):753-8. DOI: 10.1016/0014-4835(91)90110-z. View

14.

Gobbels M, Spitznas M . Corneal epithelial permeability of dry eyes before and after treatment with artificial tears. Ophthalmology. 1992; 99(6):873-8. DOI: 10.1016/s0161-6420(92)31879-2. View

15.

Tsubota K, Yamada M . Tear evaporation from the ocular surface. Invest Ophthalmol Vis Sci. 1992; 33(10):2942-50. View

16.

Wolosin J, Chen M . Ontogeny of corneal epithelial tight junctions: stratal locale of biosynthetic activities. Invest Ophthalmol Vis Sci. 1993; 34(9):2655-64. View

17.

Wang Y, Chen M, Wolosin J . ZO-1 in corneal epithelium; stratal distribution and synthesis induction by outer cell removal. Exp Eye Res. 1993; 57(3):283-92. DOI: 10.1006/exer.1993.1126. View

18.

Nakamura M, Hikida M, Nakano T, Ito S, Hamano T, Kinoshita S . Characterization of water retentive properties of hyaluronan. Cornea. 1993; 12(5):433-6. DOI: 10.1097/00003226-199309000-00010. View

19.

Tsubota K, Toda I, Yagi Y, Ogawa Y, Ono M, Yoshino K . Three different types of dry eye syndrome. Cornea. 1994; 13(3):202-9. DOI: 10.1097/00003226-199405000-00002. View

20.

Yokoi N, Kinoshita S, Akiyama K . [A new slit-lamp fluorophotometer for the clinical evaluation of corneal epithelial barrier function]. Nippon Ganka Gakkai Zasshi. 1994; 98(7):641-7. View