Ocular and Sinus Microsporidial Infection Cured with Systemic Albendazole

Overview

Journal Am J Ophthalmol

Specialty Ophthalmology

Date 1997 Aug 1

PMID 9262551

Citations 9

Authors

D C Gritz

D S Holsclaw

R E Neger

J P Whitcher Jr

T P Margolis

Affiliations

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Abstract

Purpose: To report treatment of a patient with acquired immunodeficiency syndrome (AIDS) and ocular and paranasal sinus microsporidial infection.

Method: Case report.

Results: A patient with AIDS and ocular microsporidial infection experienced resolution of ocular symptoms with topical fumagillin, but symptoms recurred upon cessation of therapy. Paranasal sinus microsporidial infection was diagnosed. The patient received sequential systemic treatment with itraconazole followed by albendazole. Sinus symptoms resolved with albendazole. He remained symptom-free with a normal examination 17 months after concluding therapy.

Conclusions: Although fumagillin and itraconazole may have played a role, systemic albendazole appears to be responsible for clinical resolution of microsporidial infection.

Citing Articles

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A Narrative Review of Microsporidial Infections of the Cornea.

Moshirfar M, Somani S, Shmunes K, Espandar L, Gokhale N, Ronquillo Y Ophthalmol Ther. 2020; 9(2):265-278.

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Unbiased Pathogen Detection and Host Gene Profiling for Conjunctivitis.

Lalitha P, Seitzman G, Kotecha R, Hinterwirth A, Chen C, Zhong L Ophthalmology. 2019; 126(8):1090-1094.

PMID: 30953744 PMC: 6646074. DOI: 10.1016/j.ophtha.2019.03.039.

Importance of clinical signs leading to the diagnosis in a case of microbiological smear negative ocular microsporidiosis.

Agarwal P, Coc I, Navon S BMJ Case Rep. 2019; 12(2).

PMID: 30709889 PMC: 6366807. DOI: 10.1136/bcr-2018-228407.