Regulation of Aquaporin-2 Water Channel Trafficking by Vasopressin

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 1997 Aug 1

PMID 9261056

Citations 39

Authors

M A Knepper

T Inoue

Affiliations

Soon will be listed here.

Abstract

Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct. The aquaporin-2 water channel has been demonstrated to be the target for this action of vasopressin. Recent studies have demonstrated that vasopressin, acting through cyclic AMP, triggers fusion of aquaporin-2-bearing vesicles with the apical plasma membrane of the collecting duct principal cells. The vesicle-targeting proteins synaptobrevin-2 and syntaxin-4 are proposed to play roles in this process.

Citing Articles

Epac induces ryanodine receptor-dependent intracellular and inter-organellar calcium mobilization in mpkCCD cells.

Yip K, Ribeiro-Silva L, Cha B, Rieg T, Sham J Front Physiol. 2023; 14:1250273.

PMID: 37711462 PMC: 10497751. DOI: 10.3389/fphys.2023.1250273.

Aldosterone Contributes to Vasopressin Escape through Changes in Water and Urea Transport.

Wang Y, LaRocque L, Ruiz J, Rodriguez E, Sands J, Klein J Biomedicines. 2023; 11(7).

PMID: 37509484 PMC: 10376660. DOI: 10.3390/biomedicines11071844.

Phosphatases Decrease Water and Urea Permeability in Rat Inner Medullary Collecting Ducts.

Wang Y, Klein J, Sands J Int J Mol Sci. 2023; 24(7).

PMID: 37047509 PMC: 10095045. DOI: 10.3390/ijms24076537.

Further evidence for functional recovery of AQP2 mutations associated with nephrogenic diabetes insipidus.

Bissonnette P, Lussier Y, Matar J, Leduc-Nadeau A, Da Cal S, Arthus M Physiol Rep. 2021; 9(11):e14866.

PMID: 34120413 PMC: 8198467. DOI: 10.14814/phy2.14866.

Adrenomedullin Inhibits Osmotic Water Permeability in Rat Inner Medullary Collecting Ducts.

Ma F, Chen G, Rodriguez E, Klein J, Sands J, Wang Y Cells. 2020; 9(12).

PMID: 33255239 PMC: 7760190. DOI: 10.3390/cells9122533.