» Articles » PMID: 9253620

Tumoral Calcinosis: a Clinicopathological Study of 111 Cases with Emphasis on the Earliest Changes

Overview
Journal Histopathology
Date 1997 Jul 1
PMID 9253620
Citations 12
Authors
Affiliations
Soon will be listed here.
Abstract

Aims: To study the pathogenesis of tumoral calcinosis (TC), we investigated 111 cases registered in Zaire over 30 years.

Methods And Results: The patients were 108 black Africans and three Caucasians between 3 and 74 years of age (mean, 37.7; median, 39). The gender was known in 33 males and 46 females; in 79 the gender was unknown. All but three were healthy and one had tuberculosis. The majority presented with a painless swelling in single or multiple periarticular regions. The hip was the most commonly affected (57%). Seven recurrences after surgical removal of the mass were reported. On microscopic examination, lesions were classified as follows: 24% stage I, 16% stage II and 60% stage III depending on the cellular activity at the border of the cysts. In five stage I cases only, and in no advanced stage II/III lesions, were exuberant cellular proliferative changes seen adjacent to the classical cystic form. These consisted of either ill-defined reactive-like perivascular solid cell nests admixed with mononuclear and iron-loaded macrophages, or well-organized variably sized fibrohistiocytic nodules embedded in a dense collagenous stroma. These immature changes indicated newly appearing lesions and were assumed to represent the earliest discernible stages in the evolution of TC. The unique well-defined fibrohistiocytic nodules have not been described previously.

Conclusions: These findings have thus described the full spectrum of lesions occurring in TC. We believe that the adjacent findings are potentially important either in recognizing early stages of the disease or in understanding its pathogenesis.

Citing Articles

Surgical Management of Tumoral Calcinosis of the Hand: A Case Report.

Gonte M, Brooks C, Klomparens K, Greenberg Y, Janevski P J Hand Microsurg. 2024; 16(2):100046.

PMID: 38855518 PMC: 11144637. DOI: 10.1055/s-0043-1771230.


A Sole Case of the FGF23 Gene Mutation c.202A>G (p.Thr68Ala) Associated with Multiple Severe Vascular Aneurysms and a Hyperphosphatemic Variant of Tumoral Calcinosis-A Case Report.

Ivanova N Life (Basel). 2024; 14(5).

PMID: 38792634 PMC: 11123361. DOI: 10.3390/life14050613.


Alterations in , , , and Genes in a Case of Late-Onset Massive Tumoral Calcinosis.

Leow M, Ang J, Bi X, Koh E, McFarlane C AACE Clin Case Rep. 2023; 9(5):153-157.

PMID: 37736313 PMC: 10509374. DOI: 10.1016/j.aace.2023.05.004.


Tumoral calcinosis in the extensor indicis proprius tendon: A case report.

AlShamsi M, AlDhamin A Clin Case Rep. 2023; 11(7):e7541.

PMID: 37397572 PMC: 10307994. DOI: 10.1002/ccr3.7541.


Recurrence of tumoral calcinosis: a case report.

Sandomenico F, Corvino A, Ronza F, Catalano O, Fazioli F, De Chiara A Acta Biomed. 2020; 90(4):587-594.

PMID: 31910191 PMC: 7233760. DOI: 10.23750/abm.v90i4.8251.