Depression in Patients with Cirrhosis. Impact on Outcome

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1997 Jul 1

PMID 9246040

Citations 25

Authors

N Singh

T Gayowski

M M Wagener

I R Marino

Affiliations

Soon will be listed here.

Abstract

The impact of depression (assessed by the Beck Depression Inventory) on quality of life and outcome was prospectively assessed in adult patients with cirrhosis. Patients with depression had significantly poorer perceived quality of life (P = 0.006), poorer adaptive coping (P = 0.001), and lower functional status, i.e., Karnofsky performance score (P = 0.06), as compared to the nondepressed patients. Survival after transplantation was not different between depressed and nondepressed patients. However, the patients with depression were significantly more likely to die while awaiting transplantation than the nondepressed patients (P = 0.02). The difference in mortality between the depressed and the nondepressed patients with end-stage liver disease could not be explained by the severity of illness variables; Child-Pugh score, complications of liver disease, renal function, serum albumin, prothrombin time, frequency and duration of hospitalizations were not significantly different for depressed and nondepressed patients. Symptoms of depression should be sought in patients with cirrhosis since depression is a modifiable illness that is amenable to treatment.

Citing Articles

The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation.

Wong R, Loeb R, Seal K, Barry F, Stark Kent D, Seetharaman S J Clin Gastroenterol. 2024; .

PMID: 39008614 PMC: 11735693. DOI: 10.1097/MCG.0000000000002028.

Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea.

Seo G, Yoo J PLoS One. 2022; 17(12):e0278924.

PMID: 36490257 PMC: 9733842. DOI: 10.1371/journal.pone.0278924.

Assessment of mental health in patients with chronic liver disease.

Whitsett M, Goswami Banerjee A, Serper M Clin Liver Dis (Hoboken). 2022; 20(2):52-56.

PMID: 36033429 PMC: 9405502. DOI: 10.1002/cld.1214.

Depressive and Anxious Symptoms in Hepatitis C Virus Infected Patients Receiving DAA-Based Therapy.

Danilescu C, Sandulescu D, Pirlog M, Streba C, Rogoveanu I Diagnostics (Basel). 2021; 11(12).

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Hemoperitoneum From Bleeding Intra-Abdominal Varices: A Rare, Life-Threatening Cause of Abdominal Pain in a Patient With Cirrhosis.

Wongjarupong N, Said H, Huynh R, Golzarian J, Lim N Cureus. 2021; 13(10):e18955.

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