Substructure of Solitary Cilia in Mouse Kidney

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1977 Sep 26

PMID 922836

Citations 11

Authors

P R Flood

G K Totland

Affiliations

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Abstract

Recent scanning electron microscopic studies confirm the presence of solitary cilia on most epithelial cells along the mammalian nephron and collecting ducts. By transmission electron microscopy we have found that the axonemata of such cilia consist of a maximal number of 9 doublet and no singlet filaments. 10% of the cross-sectioned cilia contain 9 doublets arranged in peripheral ring (9 + 0 pattern). 30% of the cross-sections contain 8 or 7 doublets in peripheral ring and 1 or 2 doublets in the central region (8 + 1 and 7 + 2 patterns). Serial sections and goniometer tilt reveal the central doublets to originate as dislodged peripheral doublets. 60% of the sectioned cilia contain filament numbers between 8 and 4. In patterns of 5 and 4 filaments single microtubules predominate. The functional significance of these atypical cilia is discussed.

Citing Articles

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Karalis V, Donovan K, Sahin M J Dev Biol. 2022; 10(4).

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Balancing the length of the distal tip by septins is key for stability and signalling function of primary cilia.

Kanamaru T, Neuner A, Kurtulmus B, Pereira G EMBO J. 2022; 41(1):e108843.

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Three-dimensional architecture of epithelial primary cilia.

Sun S, Fisher R, Bowser S, Pentecost B, Sui H Proc Natl Acad Sci U S A. 2019; 116(19):9370-9379.

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Comparative study of the primary cilia in thyrocytes of adult mammals.

Utrilla J, Gordillo-Martinez F, Gomez-Pascual A, Fernandez-Santos J, Garnacho C, Vazquez-Roman V J Anat. 2015; 227(4):550-60.

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Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella.

Pazour G, Dickert B, Vucica Y, Seeley E, Rosenbaum J, Witman G J Cell Biol. 2000; 151(3):709-18.

PMID: 11062270 PMC: 2185580. DOI: 10.1083/jcb.151.3.709.

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