Continuous Progression of Radiological Destruction in Seropositive Rheumatoid Arthritis

Overview

Journal J Rheumatol

Specialty Rheumatology

Date 1997 Jul 1

PMID 9228126

Citations 21

Authors

K Kaarela

H Kautiainen

Affiliations

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Abstract

Objective: To examine the radiographic changes in rheumatoid arthritis (RA) occurring over a 20 year period.

Methods: In 103 patients with recent (< 6 months) seropositive RA, radiographs were taken at onset and at 1, 3, 8, 15, and 20 years from entry. Larsen grades for wrist and subtalar joints were first multiplied by 5, and these together with Larsen grades for the 1st to 5th metacarpophalangeal (MCP) joints, the 1st interphalangeal, and the 2nd to 5th metatarsophalangeal (MTP) joints of the feet (24 joints) were added to form a Larsen score of 0-200. Larsen grades for the 1st to 5th MCP, wrists, and 2nd to 5th MTP (20 joints) were added to form a Larsen score of 0-100.

Results: The means of the 0-200 Larsen score were 4.3, 12.9, 26.9, 55.7, 77.5, and 86.4, and of the 0-100 Larsen score 2.5, 7.0, 13.9, 28.2, 39.4, and 44.5.

Conclusion: Seropositive RA is a chronic disease still leading to continuous progression of joint damage 20 years after onset.

Citing Articles

When Autoantibodies Are Missing: The Challenge of Seronegative Rheumatoid Arthritis.

Paroli M, Sirinian M Antibodies (Basel). 2023; 12(4).

PMID: 37987247 PMC: 10660552. DOI: 10.3390/antib12040069.

Is It the Age at Disease Onset or the Disease Radiological Severity That Affects Cervical Spine Involvement in Patients With Rheumatoid Arthritis?.

Abozaid H, El-Din Hassan R, Elmadany W, Ismail M, Elgendy D, Elsayed S Clin Med Insights Arthritis Musculoskelet Disord. 2022; 11:1179544118759688.

PMID: 35140540 PMC: 8819744. DOI: 10.1177/1179544118759688.

T helper 17 and T helper 1 cells are increased but regulatory T cells are decreased in subchondral bone marrow microenvironment of patients with rheumatoid arthritis.

Wang T, Li S, Yang Y, Zhang K, Dong S, Wang X Am J Transl Res. 2016; 8(7):2956-68.

PMID: 27508016 PMC: 4969432.

Association of PTPN22 1858C→T polymorphism, HLA-DRB1 shared epitope and autoantibodies with rheumatoid arthritis.

Raslan H, Attia H, Salama I, Ibrahim M, Mahmoud Hassan E, El Hussieny M Rheumatol Int. 2016; 36(8):1167-75.

PMID: 27324632 DOI: 10.1007/s00296-016-3511-6.

Long-term outcomes of destructive seronegative (rheumatoid) arthritis - description of four clinical cases.

Nikiphorou E, Sjowall C, Hannonen P, Rannio T, Sokka T BMC Musculoskelet Disord. 2016; 17:246.

PMID: 27256084 PMC: 4891827. DOI: 10.1186/s12891-016-1067-y.