Fat Induced Jejunal Inhibition of Gastric Acid Secretion in Duodenal Ulcer Patients Before and After Truncal Vagotomy

Overview

Journal Ann Surg

Specialty General Surgery

Date 1977 Nov 1

PMID 921350

Citations 3

Authors

J Christiansen

Affiliations

Soon will be listed here.

Abstract

The effect of intrajejunal infusion of a fat solution on pentagastrin-stimulated (0.5 microgram/kg-hr) gastric acid secretion was studied in five duodenal ulcer patients before and three to five months after truncal vagotomy. Preoperatively mean acid output was reduced from 41 +/- 5.2 meq H+/hr to 15.4 +/- 1.3 meq H+/hr (p less than 0.005), and postoperatively from 17.4 +/- 2.6 meq H+/hr to 12.7 +/- 2.4 meq H+/HR (P less than 0.01), demonstrating that fat induced jejunal inhibition of gastric acid secretion partly or wholly is humorally mediated. Furthermore the study shows that fat induced jejunal inhibition of acid secretion in duodenal ulcer patients seem to be of the same magnitude as previously found in healthy subjects.

Citing Articles

Fat inhibition of gastric acid secretion in duodenal ulcer patients before and after proximal gastric vagotomy.

Kihl B, OLBE L Gut. 1980; 21(12):1056-61.

PMID: 7007174 PMC: 1419412. DOI: 10.1136/gut.21.12.1056.

Jejunal inhibition of gastric acid secretion induced by hypertonic glucose in duodenal ulcer patients before and after truncal vagotomy.

Christiansen J, Aagaard P, Hansen T Ann Surg. 1978; 187(2):122-5.

PMID: 629614 PMC: 1396482. DOI: 10.1097/00000658-197802000-00004.

Effect of vagotomy on gastrointestinal hormones.

Becker H, Borger H, Schafmayer A World J Surg. 1979; 3(5):615-22.

PMID: 390900 DOI: 10.1007/BF01654771.

References

Middleton M, Kelly K, Nyhus L, HARKINS H . Selective vagal effects on the intestinal phase of gastric secretion. Gut. 1965; 6(3):296-300. PMC: 1552280. DOI: 10.1136/gut.6.3.296. View

Kelly K, Nyhus L, HARKINS H . THE VAGAL NERVE AND THE INTESTINAL PHASE OF GASTRIC SECRETION. Gastroenterology. 1964; 46:163-6. View

Orloff M, Abbott A, Williams R, Rosen H . Site of origin of the hormone responsible for gastric hypersecretion associated with portacaval shunt. Surgery. 1970; 68(1):202-7; discussion 207-8. View

Christiansen J, Rehfeld J, Stadil F . Effect of intrajejunal fat on meal-stimulated acid and gastrin secretion in man. Scand J Gastroenterol. 1976; 11(7):673-6. View

Ward A . The effect of vagotomy on the inhibition of gastric secretion by intraduodenal fat. Br J Surg. 1973; 60(7):533-6. DOI: 10.1002/bjs.1800600710. View

KOWALEWSKI K, Secord D . Release of gastric inhibitor from the intestine of dogs infused intravenously with sodium oleate. Pharmacology. 1974; 12(3):177-85. DOI: 10.1159/000136536. View

Henriksen F, Jorgensen S, Moller S . Interaction between secretin and cholecystokinin on inhibition of gastric secretion in man. Scand J Gastroenterol. 1974; 9(8):735-40. View

Christiansen J, Holst J, Rokkjaer M . Jejunal inhibition of pentagastrin-induced gastric acid secretion in man and Heidenhain pouch dogs. Scand J Gastroenterol. 1976; 11(2):219-24. View

Holst J, Christiansen J, Kuhl C . The enteroglucagon response to intrajejunal infusion of glucose, triglycerides, and sodium chloride, and its relation to jejunal inhibition of gastric acid secretion in man. Scand J Gastroenterol. 1976; 11(3):297-304. View

10.

Christiansen J, Holst J, Kalaja E . Inhibition of gastric acid secretion in man by exogenous and endogenous pancreatic glucagon. Gastroenterology. 1976; 70(5 PT.1):688-92. View

11.

Debas H, Slaff G, GROSSMAN M . Intestinal phase of gastric acid secretion: augmentation of maximal response of Heidenhain pouch to gastrin and histamine. Gastroenterology. 1975; 68(4 Pt 1):691-8. View

12.

Sjodin L . Inhibition of gastrin-stimulated canine acid secretion by sham-feeding. Scand J Gastroenterol. 1975; 10(1):73-80. View

13.

STENING G, GROSSMAN M . Gastric acid response to pentagastrin and histamine after extragastric vagotomy in dogs. Gastroenterology. 1970; 59(3):364-71. View

14.

Johnston D, Duthie H . Effect of fat in the duodenum on gastric acid secretion before and after vagotomy in man. Scand J Gastroenterol. 1969; 4(7):561-7. View

15.

EMAS S, GROSSMAN M . Response of Heidenhain pouch to histamine, gastrin and feeding before and after truncal vagotomy in dogs. Scand J Gastroenterol. 1969; 4(6):497-503. DOI: 10.3109/00365526909180640. View

16.

Konturek S, GROSSMAN M . Effect of perfusion of intestinal loops with acid, fat, or dextrose on gastric secretion. Gastroenterology. 1965; 49(5):481-9. View