Reduced Fertility in Mice Deficient for the POU Protein Sperm-1

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1997 Jul 8

PMID 9207130

Citations 17

Authors

R V Pearse 2nd

D W Drolet

K A Kalla

F Hooshmand

J R Bermingham Jr

M G Rosenfeld

Affiliations

Soon will be listed here.

Abstract

Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain factor that is exclusively expressed in the differentiating male germ cell. We show here that the Sprm-1 protein is expressed in the haploid spermatid and that 129/Sv Sprm-1(-/-) mice are subfertile when compared with wild-type or heterozygous littermates yet exhibit normal testicular morphology and produce normal numbers of mobile spermatozoa. Our data suggest that the Sprm-1 protein plays a discrete regulatory function in the haploid spermatid, which is required for the optimal function, but not the terminal differentiation, of the male germ cell.

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