Seroepidemiologic Studies of Hantavirus Infection Among Wild Rodents in California

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 1997 Apr 1

PMID 9204301

Citations 12

Authors

M Jay

M S Ascher

B B Chomel

M Madon

D Sesline

B A Enge

B Hjelle

T G Ksiazek

P E Rollin

P H Kass

K Reilly

Affiliations

Soon will be listed here.

Abstract

A total of 4,626 mammals were serologically tested for antibodies to Sin Nombre virus. All nonrodent species were antibody negative. Among wild rodents, antibody prevalence was 8.5% in murids, 1.4% in heteromyids, and < 0.1% in sciurids. Of 1,921 Peromyscus maniculatus (deer mice), 226 (11.8%) were antibody positive, including one collected in 1975. The highest antibody prevalence (71.4% of 35) was found among P. maniculatus on Santa Cruz Island, off the southern California coast. Prevalence of antibodies among deer mice trapped near sites of human cases (26.8% of 164) was significantly higher than that of mice from other sites (odds ratio = 4.5; 95% confidence interval = 1.7, 11.6). Antibody prevalence increased with rising elevation (> 1,200 meters) and correlated with a spatial cluster of hantavirus pulmonary syndrome cases in the Sierra Nevada.

Citing Articles

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