Macula Toxicity After Intravitreal Amikacin

Overview

Journal Aust N Z J Ophthalmol

Specialty Ophthalmology

Date 1996 May 1

PMID 9199746

Citations 9

Authors

A A Seawright

R D Bourke

R J Cooling

Affiliations

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Abstract

Background: Although intravitreal aminoglycosides have substantially improved visual prognosis in endophthalmitis, macular infarction may impair full visual recovery.

Methods: We present a case of presumed amikacin retinal toxicity following treatment with amikacin and vancomycin for alpha-haemolytic streptococcal endophthalmitis.

Results: Endophthalmitis resolved with improvement in visual acuity to 6/24 at three months. Fundus fluorescein angiography confirmed macular capillary closure and telangiectasis.

Conclusions: Currently accepted intravitreal antibiotic regimens may cause retinal toxicity and macular ischaemia. Treatment strategies aimed at avoiding retinal toxicity are discussed.

Citing Articles

Atrophy of retinal inner layers is associated with poor vision after endophthalmitis: a spectral domain optical coherence tomography study.

Lu X, Chen W, Xia H, Zheng K, Jin C, Ng D Eye (Lond). 2017; 31(10):1488-1495.

PMID: 28574491 PMC: 5639185. DOI: 10.1038/eye.2017.100.

Macular ischemia after intravitreal amikacin on patient with intraocular foreign body.

Kartasasmita A, Mona S, Iskandar E, Sovani I, Panggabean D GMS Ophthalmol Cases. 2017; 7:Doc10.

PMID: 28401030 PMC: 5366803. DOI: 10.3205/oc000061.

Safety of intravitreal quinupristin/dalfopristin in an animal model.

Giordano V, Hernandez-Da Mota S, Adabache-Guel T, Castillejos-Chevez A, Corredor-Casas S, Salinas-Longoria S Int J Ophthalmol. 2016; 9(3):373-8.

PMID: 27158605 PMC: 4844051. DOI: 10.18240/ijo.2016.03.08.

Susceptibility of bacterial isolates to vancomycin and ceftazidime from patients with endophthalmitis: Is there a need to change the empirical therapy in suspected bacterial endophthalmitis?.

Reddy A, Reddy R, Paruvelli M, Ambatipudi S, Rani A, K Lodhi S Int Ophthalmol. 2014; 35(1):37-42.

PMID: 25384628 DOI: 10.1007/s10792-014-0015-9.

A prospective multicenter randomized placebo-controlled trial of dexamethasone as an adjuvant in the treatment of postoperative bacterial endophthalmitis: interim safety analysis of the study drug and analysis of overall treatment results.

Lindstedt E, Bennebroek C, Van Der Werf D, Veckeneer M, Ossewaarde-van Norel A, Mayland Nielsen C Graefes Arch Clin Exp Ophthalmol. 2014; 252(10):1631-7.

PMID: 25107542 DOI: 10.1007/s00417-014-2770-8.