Nutritional Impact of Antipseudomonas Intravenous Antibiotic Courses in Cystic Fibrosis

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1997 May 1

PMID 9196361

Citations 1

Authors

P Vic

S Ategbo

F Gottrand

V Launay

G A Loeuille

J C Elian

D Druon

J P Farriaux

D Turck

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the short term effects on nutritional status of home intravenous anti-pseudomonas antibiotic courses in cystic fibrosis (CF) patients chronically colonised with Pseudomonas aeruginosa.

Design: A prospective study involving 38 CF patients, mean age 10.9 (SD 4.3) years (range 4.3 to 22.2 years), presenting with pulmonary exacerbations of P aeruginosa infection. The patients received a 14 day antibiotic course of intravenous ceftazidime (200 mg/kg/day) and either amikacin (35 mg/kg/day) or tobramycin (15 mg/kg/day). Nutritional evaluation on days 1 and 14 involved measurements of weight, weight/height ratio (per cent of predicted value), energy intake (per cent of recommended daily allowances), serum prealbumin, and body composition assessed by two methods: bioelectrical analysis (BIA) and skinfold anthropometry. The non-parametric Wilcoxon t test was used for statistical analysis, with a Bland-Altman plot to assess the degree of agreement between the two methods of evaluating body composition.

Results: Weight increased by 1.0 (0.8) kg (p < 0.001); weight/height increased from 94.4(12.2)% to 98(12.7)% (p < 0.001), energy intake from 107(32)% to 119(41)% (p < 0.02), and prealbumin from 183 (63) to 276 (89) mg/l (p < 0.001). Fat mass increased by 0.8 (1.0) kg (p < 0.001), without any significant change in fat-free mass. The limits of agreement between BIA and anthropometry were -0.7 kg and +1.1 kg.

Conclusions: Antibiotic courses allow an improvement in nutritional status in CF patients, with a gain in fat mass.

Citing Articles

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis.

Hurley M, Prayle A, Flume P Cochrane Database Syst Rev. 2015; (7):CD009730.

PMID: 26226131 PMC: 6481905. DOI: 10.1002/14651858.CD009730.pub2.

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