Quantification of Left Ventricular Function with Thallium-201 and Technetium-99m-sestamibi Myocardial Gated SPECT

Overview

Journal J Nucl Med

Specialty Nuclear Medicine

Date 1997 Jun 1

PMID 9189150

Citations 24

Authors

C Maunoury

C C Chen

K B Chua

C J Thompson

Affiliations

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Abstract

Unlabelled: Myocardial gated SPECT with 99mTc-sestamibi has been used to quantify left ventricular function. The purpose of this study was to determine if myocardial gated SPECT with 201Tl was possible and reliable to quantify left ventricular function.

Methods: One hundred and four patients referred for a myocardial perfusion study were included. Myocardial gated SPECT acquisition was performed 15 min after the intravenous injection of 111 MBq (3mCi) 201Tl and at 1 hr postinjection of 925 MBq (25 mCi) 99mTc-sestamibi. A commercially available automated myocardial gated SPECT processing software was used. Parameters evaluated were left ventricular ejection fractions (LVEF), end-diastolic volumes (EDV), end-systolic volumes (ESV) and stroke volumes (SV).

Results: The correlation between gated SPECT with 201Tl and gated SPECT with 99mTc-sestamibi was: r = 0.93 for LVEF, 0.92 for EDV, 0.96 for ESV and 0.68 for SV.

Conclusion: Myocardial gated SPECT quantification of left ventricular function with 201Tl was possible and as reliable as gated SPECT with 99mTc-sestamibi. There was excellent correlation between gated SPECT with 201Tl and gated SPECT with 99mTc-sestamibi. In addition to assessment of myocardial perfusion, myocardial function and viability can be quantified in a single gated 201Tl study.

Citing Articles

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Thallium-201 gated single-photon emission tomography for assessing left ventricular volumes and function in patients with aortic valve stenosis: Comparison with echocardiography as the reference standard.

Kurisu S, Iwasaki T, Ikenaga H, Watanabe N, Higaki T, Shimonaga T Int J Cardiol Heart Vasc. 2017; 5:74-78.

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Do reconstruction filters really effect the volume and ejection fraction calculation with 99Tc-sestamibigated myocardial SPECT?.

Manish O, Kheruka S, Barai S, Gambhir S Indian J Nucl Med. 2011; 25(4):156-9.

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Dynamic single photon emission computed tomography--basic principles and cardiac applications.

Gullberg G, Reutter B, Sitek A, Maltz J, Budinger T Phys Med Biol. 2010; 55(20):R111-91.

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Left ventricular ejection fraction assessment by Tl-201 gated SPECT: a comparison with echocardiography.

Harpaz D, Asman A, Kuperstein R, Boaz M, Chouraqui P Clin Cardiol. 2010; 33(3):E56-62.

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