Bripiodionen, a New Inhibitor of Human Cytomegalovirus Protease from Streptomyces Sp. WC76599

Overview

Journal J Nat Prod

Date 1997 May 1

PMID 9170296

Citations 4

Authors

Y Z Shu

Q Ye

J M Kolb

S Huang

J A Veitch

S E Lowe

S P Manly

Affiliations

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Abstract

Bripiodionen (1), a new natural product, was isolated from Streptomyces sp. WC76599 during the screening of microbial fermentation extracts for their ability to inhibit human cytomegalovirus protease. The structure of 1 was elucidated by spectroscopic methods. Compound 1 displayed inhibitory activity against human cytomegalovirus protease with an IC50 value of 30 microM.

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