Dynamic Changes in Nucleus Accumbens Dopamine Efflux During the Coolidge Effect in Male Rats

Overview

Journal J Neurosci

Specialty Neurology

Date 1997 Jun 15

PMID 9169543

Citations 46

Authors

D F Fiorino

A. Coury

A G Phillips

Affiliations

Soon will be listed here.

Abstract

The Coolidge effect describes the reinitiation of sexual behavior in a "sexually satiated" animal in response to a novel receptive mate. Given the role of the mesolimbic dopamine (DA) system in the initiation and maintenance of motivated behavior, microdialysis was used to monitor nucleus accumbens (NAC) DA transmission during copulation, sexual satiety, and the reinitiation of sexual behavior. In agreement with earlier reports, the presentation of an estrous female behind a screen and copulation were associated with significant increases in NAC DA efflux. Return of NAC DA concentrations to baseline values coincided with a period of sexual satiety, although concentrations of the DA metabolites, dihydroxyphenylacetic acid and homovanillic acid, remained elevated. The presentation of a novel receptive female behind a screen resulted in a slight increase in NAC DA, which was augmented significantly during renewed copulation with the novel female. The present data suggest that the stimulus properties of a novel receptive female may serve to increase NAC DA transmission in a sexually satiated male rat, and this, in turn, may be related to the reinitiation of sexual behavior.

Citing Articles

Pornography Consumption and Cognitive-Affective Distress.

Privara M, Bob P J Nerv Ment Dis. 2023; 211(8):641-646.

PMID: 37505898 PMC: 10399954. DOI: 10.1097/NMD.0000000000001669.

The endogenous cannabinoid system modulates male sexual behavior expression.

Rodriguez-Manzo G, Canseco-Alba A Front Behav Neurosci. 2023; 17:1198077.

PMID: 37324524 PMC: 10264596. DOI: 10.3389/fnbeh.2023.1198077.

Crosstalk between the endocannabinoid and mid-brain dopaminergic systems: Implication in dopamine dysregulation.

Kibret B, Canseco-Alba A, Onaivi E, Engidawork E Front Behav Neurosci. 2023; 17:1137957.

PMID: 37009000 PMC: 10061032. DOI: 10.3389/fnbeh.2023.1137957.

Sexual satiety modifies methamphetamine-induced locomotor and rewarding effects and dopamine-related protein levels in the striatum of male rats.

Violante-Soria V, Cruz S, Rodriguez-Manzo G Psychopharmacology (Berl). 2023; 240(4):797-812.

PMID: 36745226 DOI: 10.1007/s00213-023-06322-w.

Flexibility of neural circuits regulating mating behaviors in mice and flies.

Karigo T, Deutsch D Front Neural Circuits. 2022; 16:949781.

PMID: 36426135 PMC: 9679785. DOI: 10.3389/fncir.2022.949781.

References

Zetterstrom T, Sharp T, Ungerstedt U . Effect of neuroleptic drugs on striatal dopamine release and metabolism in the awake rat studied by intracerebral dialysis. Eur J Pharmacol. 1984; 106(1):27-37. DOI: 10.1016/0014-2999(84)90674-5. View

Shimura T, Yamamoto T, SHIMOKOCHI M . The medial preoptic area is involved in both sexual arousal and performance in male rats: re-evaluation of neuron activity in freely moving animals. Brain Res. 1994; 640(1-2):215-22. DOI: 10.1016/0006-8993(94)91875-9. View

Fowler H, Whalen R . Variation in incentive stimulus and sexual behavior in the male rat. J Comp Physiol Psychol. 1961; 54:68-71. DOI: 10.1037/h0046549. View

Wilson J, KUEHN R, BEACH F . Modification in the sexual behavior of male rats produced by changing the stimulus female. J Comp Physiol Psychol. 1963; 56:636-44. DOI: 10.1037/h0042469. View

Imperato A, Di Chiara G . Dopamine release and metabolism in awake rats after systemic neuroleptics as studied by trans-striatal dialysis. J Neurosci. 1985; 5(2):297-306. PMC: 6565211. View

Kalivas P, Sorg B, Hooks M . The pharmacology and neural circuitry of sensitization to psychostimulants. Behav Pharmacol. 1993; 4(4):315-334. View

Holmes G, Holmes D, Sachs B . An IBM-PC based data collection system for recording rodent sexual behavior and for general event recording. Physiol Behav. 1988; 44(6):825-8. DOI: 10.1016/0031-9384(88)90070-4. View

Kaba H, Hayashi Y, Higuchi T, Nakanishi S . Induction of an olfactory memory by the activation of a metabotropic glutamate receptor. Science. 1994; 265(5169):262-4. DOI: 10.1126/science.8023145. View

Rodriguez-Manzo G, Fernandez-Guasti A . Reversal of sexual exhaustion by serotonergic and noradrenergic agents. Behav Brain Res. 1994; 62(2):127-34. DOI: 10.1016/0166-4328(94)90019-1. View

10.

Blackburn J, Pfaus J, Phillips A . Dopamine functions in appetitive and defensive behaviours. Prog Neurobiol. 1992; 39(3):247-79. DOI: 10.1016/0301-0082(92)90018-a. View

11.

Mas M, Gonzalez-Mora J, Louilot A, Sole C, Guadalupe T . Increased dopamine release in the nucleus accumbens of copulating male rats as evidenced by in vivo voltammetry. Neurosci Lett. 1990; 110(3):303-8. DOI: 10.1016/0304-3940(90)90864-6. View

12.

Pleim E, Matochik J, Barfield R, Auerbach S . Correlation of dopamine release in the nucleus accumbens with masculine sexual behavior in rats. Brain Res. 1990; 524(1):160-3. DOI: 10.1016/0006-8993(90)90507-8. View

13.

Mas M, Fumero B, Gonzalez-Mora J . Voltammetric and microdialysis monitoring of brain monoamine neurotransmitter release during sociosexual interactions. Behav Brain Res. 1995; 71(1-2):69-79. DOI: 10.1016/0166-4328(95)00043-7. View

14.

Wenkstern D, Pfaus J, Fibiger H . Dopamine transmission increases in the nucleus accumbens of male rats during their first exposure to sexually receptive female rats. Brain Res. 1993; 618(1):41-6. DOI: 10.1016/0006-8993(93)90426-n. View

15.

Mirenowicz J, Schultz W . Importance of unpredictability for reward responses in primate dopamine neurons. J Neurophysiol. 1994; 72(2):1024-7. DOI: 10.1152/jn.1994.72.2.1024. View

16.

Wilson C, Nomikos G, Collu M, Fibiger H . Dopaminergic correlates of motivated behavior: importance of drive. J Neurosci. 1995; 15(7 Pt 2):5169-78. PMC: 6577888. View

17.

Pfaus J, Gorzalka B . Opioids and sexual behavior. Neurosci Biobehav Rev. 1987; 11(1):1-34. DOI: 10.1016/s0149-7634(87)80002-7. View

18.

Sato Y, Wada H, Horita H, Suzuki N, Shibuya A, Adachi H . Dopamine release in the medial preoptic area during male copulatory behavior in rats. Brain Res. 1995; 692(1-2):66-70. DOI: 10.1016/0006-8993(95)00656-b. View

19.

Hull E, Du J, Lorrain D, Matuszewich L . Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation. J Neurosci. 1995; 15(11):7465-71. PMC: 6578034. View

20.

Mas M, Fumero B . Induction of mating behavior by apomorphine in sexually sated rats. Eur J Pharmacol. 1995; 280(3):331-4. DOI: 10.1016/0014-2999(95)00270-u. View