Two Cases of Monoclonal Immunoglobulins with Antistreptolysin Activity: Clinical and Laboratory Study

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1977 Sep 1

PMID 915012

Citations 1

Authors

F A Lustermans

F Klein

Affiliations

Soon will be listed here.

Abstract

In two patients with a persisting, high antistreptolysin titre the antistreptolysin activity in both cases resided exclusively in a monoclonal IgG component in the serum. This component had all the characteristics of a true antibody. A history in both patients of arthritis with or without angina suggested that the monoclonal antibodies were reactive in origin, although definite proof was lacking. In one case there was a suggestion of incipient myeloma. Whenever an extremely high antistreptolysin titre persists after antibiotic treatment the possibility of paraproteinaemia should be considered.

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Seigneurin J, Renversez J, Baccard M, Seigneurin D, Micouin C Clin Exp Immunol. 1980; 41(2):317-25.

PMID: 6254708 PMC: 1536997.

References

Levy H, SOBER H . A simple chromatographic method for preparation of gamma globulin. Proc Soc Exp Biol Med. 1960; 103:250-2. DOI: 10.3181/00379727-103-25476. View

WALDENSTROEM J, Winblad S, HAELLEN J, LIUNGMAN S . THE OCCURRENCE OF SEROLOGICAL "ANTIBODY" REAGINS OR SIMILAR GAMMA-GLOBULINS IN CONDITIONS WITH MONOCLONAL HYPERGAMMAGLOBULINEMIA, SUCH AS MYELOMA, MACROGLOBULINEMIA ETC. Acta Med Scand. 1964; 176:619-31. DOI: 10.1111/j.0954-6820.1964.tb00666.x. View

WALDENSTROEM J . THE OCCURRENCE OF BENIGN, ESSENTIAL MONOCLONAL (M TYPE), NON-MACROMOLECULAR HYPERGLOBULINEMIA AND ITS DIFFERENTIAL DIAGNOSIS. IV. STUDIES IN THE GAMMAPATHIES. Acta Med Scand. 1964; 176:345-65. View

Nisonoff A, Mandy W . Quantitative estimation of the hybridization of rabbit antibodies. Nature. 1962; 194:355-9. DOI: 10.1038/194355a0. View

Beaumont J . [Gamma globulins and hyperlipemia. Hyperlipemia caused by autoantibodies]. Ann Biol Clin (Paris). 1969; 27(10):611-35. View

Yount W, DORNER M, KUNKEL H, KABAT E . Studies on human antibodies. VI. Selective variations in subgroup composition and genetic markers. J Exp Med. 1968; 127(3):633-46. PMC: 2138455. DOI: 10.1084/jem.127.3.633. View

KLEIN G, Baker C, ADDISON B, Moody M . Micro test for streptococcal anti-deoxyribonuclease B. Appl Microbiol. 1969; 18(2):204-6. PMC: 377944. DOI: 10.1128/am.18.2.204-206.1969. View

Wager O, Rasanen J, HALTIA K, Wasastjerna C . M components with antibody activity. Anti-smooth muscle, anti-thyroglobulin and anti-streptolysin-O activity in five M component sera. Ann Clin Res. 1971; 3(2):86-97. View

Potter M . Myeloma proteins (M-components) with antibody-like activity. N Engl J Med. 1971; 284(15):831-8. DOI: 10.1056/NEJM197104152841507. View

10.

Kronvall G . Ligand-binding sites for streptolysin O and staphylococcal protein A on different parts of the same myeloma globulin. Acta Pathol Microbiol Scand. 1967; 69(4):619-21. DOI: 10.1111/j.1699-0463.1967.tb03776.x. View

11.

Osterland C, Miller E, KARAKAWA W, Krause R . Characteristics of streptococcal group-specific antibody isolated from hyperimmune rabbits. J Exp Med. 1966; 123(4):599-614. PMC: 2180455. DOI: 10.1084/jem.123.4.599. View

12.

SELIGMANN M, Sassy C, Chevalier A . A human IgG myeloma protein with anti- 2 macroglobulin antibody activity. J Immunol. 1973; 110(1):85-90. View

13.

Sauvezie B, Missioux D, Leroy V, Wahl D, Goumy P, Bussiere J . [A further case of myeloma with paraprotein showing antistreptolysin O activity (unusual visceral signs, radiological regression under treatment]. Rev Rhum Mal Osteoartic. 1974; 41(6):449-53. View

14.

Riesen W, Morell A . A human myeloma protein with specificity against dinitrophenyl and nucleic acid derivatives. Immunochemistry. 1972; 9(10):979-85. DOI: 10.1016/0019-2791(72)90109-7. View

15.

HARBOE M, Torsvik H . Protein abnormalities in the cold haemagglutinin syndrome. Scand J Haematol. 1969; 6(6):416-26. DOI: 10.1111/j.1600-0609.1969.tb01836.x. View

16.

Feizi T, Schumacher M . Light chain homogeneity of post-infective cold agglutinins. Clin Exp Immunol. 1968; 3(9):923-9. PMC: 1579019. View

17.

Eichmann K, Braun D, Krause R . Influence of genetic factors on the magnitude and the heterogeneity of the immune response in the rabbit. J Exp Med. 1971; 134(1):48-65. PMC: 2139032. DOI: 10.1084/jem.134.1.48. View

18.

Roholt O, Seon B, Pressman D . Antibodies of limited heterogeneity: L chains of a single mobility. Immunochemistry. 1970; 7(4):329-40. DOI: 10.1016/0019-2791(70)90236-3. View

19.

Klein F, van Rood J, Van Furth R, Radema H . IgM-IgG cryoglobulinaemia with IgM paraprotein component. Clin Exp Immunol. 1968; 3(7):703-16. PMC: 1578986. View

20.

SELIGMANN M, DANON F, Basch A, Bernard J . IgG myeloma cryoglobulin with antistreptolysin activity. Nature. 1968; 220(5168):711-2. DOI: 10.1038/220711a0. View