High-performance Thin-layer Chromatographic Determination of Psychopharmacologic Agents in Blood Serum
Overview
Authors
Affiliations
High-performance thin-layer chromatography affords a rapid, sensitive method for determination of psychopharmacologic agents in blood serum samples. Quantitation of the representative drugs chlorpromazine, amitriptyline, nortriptyline, imipramine, and desipramine at levels as low as 5 ng/ml is demonstrated by scanning the developed thin-layer plates with a chromatographic spectrophotometer in the ultraviolet absorption mode. Neither derivatization prior to, nor color development after chromatographic separation is required to achieve sensitivity and reproducibility of determinations.
Clinical pharmacokinetics of drugs used to treat urge incontinence.
Guay D Clin Pharmacokinet. 2003; 42(14):1243-85.
PMID: 14606931 DOI: 10.2165/00003088-200342140-00004.
Dose-dependent kinetics of imipramine in elderly patients.
Bjerre M, Gram L, Kragh-Sorensen P, Kristensen C, Pedersen O, Moller M Psychopharmacology (Berl). 1981; 75(4):354-7.
PMID: 6803279 DOI: 10.1007/BF00435852.
Cardiovascular effect of imipramine and nortriptyline in elderly patients.
Thayssen P, Bjerre M, Kragh-Sorensen P, Moller M, Petersen O, Kristensen C Psychopharmacology (Berl). 1981; 74(4):360-4.
PMID: 6794083 DOI: 10.1007/BF00432748.
Orthostatic side effects of clomipramine and citalopram during treatment for depression.
Christensen P, Thomsen H, Pedersen O, Gram L, Kragh-Sorensen P Psychopharmacology (Berl). 1985; 86(4):383-5.
PMID: 3929308 DOI: 10.1007/BF00427895.