Studies on Bone Ion Exchanges Using Multiple-tracer Indicator-dilution Techniques

Overview

Journal Fed Proc

Specialties Biology
Physiology

Date 1977 Nov 1

PMID 913623

Citations 9

Authors

P J Kelly

J B Bassingthwaighte

Affiliations

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Abstract

Free diffusion appears to be the principal mechanism for movement of ions, known to concentrate in bone, across the capillaries of bone. The interstitial fluid space appears large enough to allow for determination of instantaneous fractional escape by the indicator-dilution method. The mechanism by which large molecules, such as the diphosphonate 99mTc-labeled EHDP or 99mTc-labeled pyrophosphate, pass through capillaries in bone is by passive diffusion. These molecules are larger than 85Sr and their lower extraction rate is presumably due to the effect of their sizes on passage through transcapillary clefts. A corollary of these studies might be that if transcapillary exchange is passive, then partition of anions and cations likely lies beyond the capillary and therefore is controlled by osteal cellular processes.

Citing Articles

Physiology of bone turnover and its application in contemporary maxillofacial surgery. A review.

Iliopoulos C, Zouloumis L, Lazaridou M Hippokratia. 2011; 14(4):244-8.

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Exchange of potassium and strontium in adult bone.

Maltby B, Lemon G, Bassingthwaighte J, Kelly P Am J Physiol. 1982; 242(4):H705-12.

PMID: 7065283 PMC: 2879881. DOI: 10.1152/ajpheart.1982.242.4.H705.

Influence of parathyroid state on calcium uptake in bone.

Lemon G, Bassingthwaighte J, Kelly P Am J Physiol. 1982; 242(3):E146-53.

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Skeletal uptake of diphosphonate: a review.

Fogelman I Eur J Nucl Med. 1980; 5(6):473-6.

PMID: 7007051 DOI: 10.1007/BF00252034.

Anatomy of the microvasculature of the tibial diaphysis of the adult dog.

Bassingthwaighte J, Kelly P J Bone Joint Surg Am. 1980; 62(8):1362-9.

PMID: 7002933 PMC: 2922392.

References

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