Evidence for an HLA-linked Resistance Gene in Buerger's Disease

Overview

Journal Tissue Antigens

Date 1979 Aug 1

PMID 91227

Citations 6

Authors

P de Moerloose

M Jeannet

P Mirimanoff

C A BOUVIER

Affiliations

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Abstract

The incidence of Thromboangiitis Obliterans in brothers and the high prevalence in some ethnic groups have led us to investigate the histocompatibility HLA-A, B and DR antigens of 46 Buerger's disease patients. The main result indicates a marked decreased freqeuncy of the B12 antigen: 2.2% vs 28% in controls. Our study suggests that Buerger's disease is, on the basis of HLA antigens, a distinct immunogenetic entity and not a particular form of arteriosclerosis. Moreover, this disorder may represent a clue to the existence of resistance genes linked to HLA.

Citing Articles

The Association of HLA-A, B and DRB1 with Buerger's Disease.

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Activation of cytokines corroborate with development of inflammation and autoimmunity in thromboangiitis obliterans patients.

Dellalibera-Joviliano R, Joviliano E, Silva J, Evora P Clin Exp Immunol. 2012; 170(1):28-35.

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Baumann G, Stangl V, Klein-Weigel P, Stangl K, Laule M, Enke-Melzer K Clin Res Cardiol. 2011; 100(8):683-90.

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Thromboangiitis obliterans (Buerger's disease).

Arkkila P Orphanet J Rare Dis. 2006; 1:14.

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Clinical and radiologic aspects of Buerger's disease.

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