Neural Targeting of Mycobacterium Leprae Mediated by the G Domain of the Laminin-alpha2 Chain

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 1997 Mar 21

PMID 9118224

Citations 45

Authors

A Rambukkana

J L Salzer

P D Yurchenco

E I Tuomanen

Affiliations

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Abstract

We report that the molecular basis of the neural tropism of Mycobacterium leprae is attributable to the specific binding of M. leprae to the laminin-alpha2 (LN-alpha2) chain on Schwann cell-axon units. Using recombinant fragments of LN-alpha2 (rLN-alpha2), the M. leprae-binding site was localized to the G domain. rLN-alpha2G mediated M. leprae binding to cell lines and to sciatic nerves of dystrophic dy/dy mice lacking LN-alpha2, but expressing laminin receptors. Anti-beta4 integrin antibody attenuated rLN-alpha2G-mediated M. leprae adherence, suggesting that M. leprae interacts with cells by binding to beta4 integrin via an LN-alpha2G bridge. Our results indicate a novel role for the G domain of LN-2 in infection and reveal a model in which a host-derived bridging molecule determines nerve tropism of a pathogen.

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