Modulation of Phosphorylation of Neuronal Cytoskeletal Proteins by Neuronal Depolarization

Overview

Journal Cell Mol Neurobiol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Neurology

Date 1997 Feb 1

PMID 9118204

Citations 2

Authors

M Mata

P Honegger

D J Fink

Affiliations

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Abstract

1. The neuronal cytoskeletal protein tau and the carboxy tails of cytoskeletal proteins neurofilament-M (NF-M) and neurofilament-H (NF-H) are phosphorylated on serine residues by the cyclin-dependent kinase cdk-5. 2. In aggregating neuronal-glial cultures we show that veratridine-mediated cation influx causes dephosphorylation of tau, NF-M and NF-H. Dephosphorylation was blocked specifically by cyclosporine A but not by okadiac acid at concentrations up to 200 nM. 3. These results suggest that veratridine-triggered cation influx causes activation of PP-2B (calcineurin) leading to dephosphorylation of these cytoskeletal proteins.

Citing Articles

Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments.

Veeranna , Yang D, Lee J, Vinod K, Stavrides P, Amin N Neurobiol Aging. 2009; 32(11):2016-29.

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Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5.

Wang S, Zhu L, Shi H, Zheng H, Tian Q, Wang Q Neurochem Res. 2007; 32(8):1329-35.

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