Incidence of Intracranial Aneurysm Associated with Pituitary Adenoma

Overview

Journal Neurosurg Rev

Specialty Neurosurgery

Date 1997 Jan 1

PMID 9085282

Citations 42

Authors

B Pant

K Arita

K Kurisu

A Tominaga

K Eguchi

T Uozumi

Affiliations

Soon will be listed here.

Abstract

The incidence of intracranial aneurysm associated with pituitary adenoma is not definitely established although reported higher than in general population. This study was designed to find the existence of such association in a large series of pituitary adenoma cases. A retrospective study of 467 cases of pituitary adenoma (mean age: 41 +/- 15 years) was done. All patients underwent cerebral angiography at least of anterior circulation, detailed hormonal study, and 155 cases had additional magnetic resonance (MR) angiography. Twenty-five cases (5.4%) of pituitary adenoma (mean age 52 years) had intracranial aneurysm, 97% on anterior circulation, and 12% had multiple aneurysms. Two cases presented with aneurysmal rupture and the rest were incidental. Aneurysm was more frequently seen with increasing age (p < 0.001) and the age distribution resembled that of aneurysm among general population. Although the combination was most frequent among nonfunctioning adenoma (8.8%), and least frequent among prolactinoma (2.4%), this association was again due to age factor. There was no association between hormone secretion, size and invasive nature of the tumor. The results showed no association between intracranial aneurysm and pituitary adenoma. Our speculation is that such occurrence is merely a chance factor and the risk is no greater than that among general population.

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References

Arita K, Uozumi T, Oki S, Kuwabara S, Ohba S, Nakahara T . Moyamoya disease associated with pituitary adenoma--report of two cases. Neurol Med Chir (Tokyo). 1992; 32(10):753-7. DOI: 10.2176/nmc.32.753. View

Mangiardi J, Aleksic S, LIFSHITZ M, Pinto R, Budzilovic G, Pearson J . Coincidental pituitary adenoma and cerebral aneurysm with pathological findings. Surg Neurol. 1983; 19(1):38-41. DOI: 10.1016/0090-3019(83)90208-2. View

Acqui M, Ferrante L, Fraioli B, Cosentino F, Fortuna A, Mastronardi L . Association between intracranial aneurysms and pituitary adenomas. AEtiopathogenetic hypotheses. Neurochirurgia (Stuttg). 1987; 30(6):177-81. DOI: 10.1055/s-2008-1054091. View

DU BOULAY G . Some observations on the natural history of intracranial aneurysms. Br J Radiol. 1965; 38(454):721-57. DOI: 10.1259/0007-1285-38-454-721. View

JAKUBOWSKI J, Kendall B . Coincidental aneurysms with tumours of pituitary origin. J Neurol Neurosurg Psychiatry. 1978; 41(11):972-9. PMC: 493208. DOI: 10.1136/jnnp.41.11.972. View

Nakagawa T, Hashi K . The incidence and treatment of asymptomatic, unruptured cerebral aneurysms. J Neurosurg. 1994; 80(2):217-23. DOI: 10.3171/jns.1994.80.2.0217. View

HOUSEPIAN E, POOL J . A systematic analysis of intracranial aneurysms from the autopsy file of the Presbyterian Hospital, 1914 to 1956. J Neuropathol Exp Neurol. 1958; 17(3):409-23. DOI: 10.1097/00005072-195807000-00001. View

Sekhar L, Heros R . Origin, growth, and rupture of saccular aneurysms: a review. Neurosurgery. 1981; 8(2):248-60. DOI: 10.1227/00006123-198102000-00020. View

Lippman H, Onofrio B, BAKER Jr H . Intrasellar aneurysm and pituitary adenoma: report of a case. Mayo Clin Proc. 1971; 46(8):532-5. View

10.

Wakai S, Fukushima T, Furihata T, Sano K . Association of cerebral aneurysm with pituitary adenoma. Surg Neurol. 1979; 12(6):503-7. View

11.

Okada H, Kodama N, Mineura K, Sakamoto T, Suzuki J . [A ruptured aneurysm associated with pituitary tumor (author's transl)]. No Shinkei Geka. 1980; 8(4):379-81. View

12.

Jordan R, Kerber C . Rupture of a parasellar aneurysm with a coexisting pituitary tumor. South Med J. 1978; 71(6):741-2. DOI: 10.1097/00007611-197806000-00038. View

13.

White J, BALLANTINE Jr H . Intrasellar aneurysms simulating hypophyseal tumours. J Neurosurg. 1961; 18:34-50. DOI: 10.3171/jns.1961.18.1.0034. View

14.

Handa J, Matsuda I, Handa H . Association of brain tumor and intracranial aneurysms. Surg Neurol. 1976; 6(1):25-9. View

15.

MCCORMICK W . The size of intracranial saccular aneurysms. An autopsy study. J Neurosurg. 1970; 33(4):422-7. DOI: 10.3171/jns.1970.33.4.0422. View

16.

Tsuchida T, Tanaka R, Yokoyama M, Sato H . Rupture of anterior communicating artery aneurysm during transsphenoidal surgery for pituitary adenoma. Surg Neurol. 1983; 20(1):67-70. DOI: 10.1016/0090-3019(83)90110-6. View