The Synthesis of Total and Specific Glycosaminoglycans During Development of Experimental Liver Cirrhosis

Overview

Journal Experientia

Specialty Science

Date 1977 Oct 15

PMID 908398

Citations 3

Authors

A M Gressner

H Pazen

H Greiling

Affiliations

Soon will be listed here.

Abstract

During hepatic fibrogenesis induced by long-term administration of thioacetamide, the synthesis of chondroitin 4,6-sulfate and hyaluronic acid was strongly enhanced; the formation of heparan sulfate comprising at least 70% of total liver GAG synthesis and of a keratan-sulfate-like fraction was stimulated 1.7 fold. Formation of dermatan-sulfate in liver could not be detected.

Citing Articles

Altered Proteoglycan Gene Expression in Human Biliary Cirrhosis.

Kovalszky I I, Nagy J, Gallai M, Sebestyen A, Schaff Z, Paku S Pathol Oncol Res. 1997; 3(1):51-58.

PMID: 11173626 DOI: 10.1007/BF02893354.

The chemical morphology of extracellular matrix in experimental rat liver fibrosis resembles that of normal developing connective tissue.

Scott J, Bosworth T, Cribb A, Gressner A Virchows Arch. 1994; 424(1):89-98.

PMID: 7526948 DOI: 10.1007/BF00197398.

Extracellular glycosaminoglycans (GAG) released by chick embryonic fibroblasts. A possible involvement of surface receptors.

Evangelisti R, Bodo M, Caruso A, Becchetti E, Carinci P Cell Tissue Res. 1984; 238(2):241-5.

PMID: 6096000 DOI: 10.1007/BF00217295.

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