In Vivo Genotoxicity of Selected Herbicides in the Mouse Bone-marrow Micronucleus Test

Overview

Journal Arch Toxicol

Specialty Toxicology

Date 1997 Jan 1

PMID 9049057

Citations 10

Authors

T Gebel

S Kevekordes

K Pav

R Edenharder

H Dunkelberg

Affiliations

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Abstract

The herbicides alachlor, atrazine, terbuthylazine, gluphosinate-ammonium, isoproturon, pendimethaline and trifluralin were tested for genotoxicity in the mouse bone-marrow micronucleus test (MNT). Both atrazine and trifluraline caused a significant increase in the number of micronuclei at doses of 1,400 mg/kg body weight in female mice only. Alachlor, terbuthylazine, gluphosinate-ammonium, isoproturon and pendimethaline did not have any genotoxic effect in the mouse bone-marrow micronucleus test in either female or male animals.

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