Brainstem-mediated Locomotion and Myoclonic Jerks. I. Neural Substrates

Overview

Journal Brain Res

Specialty Neurology

Date 1997 Jan 16

PMID 9037417

Citations 12

Authors

Y Y Lai

J M Siegel

Affiliations

Soon will be listed here.

Abstract

Eleven of 40 decerebrated cats were found to exhibit periods of spontaneous or sensory myoclonus and locomotion beginning 24 h after decerebration. Histological analysis showed that the cats generating myoclonus hemorrhagic lesions in the retrorubral nucleus (RRN) and ventral mesopontine junction (vMPJ). However, with intact RRN and vMPJ never showed myoclonus. To verify that the lesions were responsible for myoclonus, 6 additional cats received N-methyl-D-aspartate (NMDA, 0.5 M/0.5 microliter) injections in the areas of RRN and vMPJ to produce bilateral lesions. Coordinated rhythmic leg movement (locomotion) or myoclonic twitches developed in all of these cats beginning 3 hours after NMDA injection. These NMDA lesion-induced movements appeared either spontaneously (5 out of 6 cats) or after sensory stimulation (1 cat). Four cats received saline control injections in the RRN and vMPJ and did not have spontaneous, or sensory stimulation-induced, myoclonic twitches during the 48 h observation period. These results indicate that the RRN and vMPJ have a suppressive effect on myoclonic twitches and rhythmic leg movement. Dysfunction of these regions could release motor activity into sleep and waking states.

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References

Montplaisir J, Godbout R, Poirier G, Bedard M . Restless legs syndrome and periodic movements in sleep: physiopathology and treatment with L-dopa. Clin Neuropharmacol. 1986; 9(5):456-63. DOI: 10.1097/00002826-198610000-00006. View

Lai Y, Siegel J . Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation. J Neurosci. 1990; 10(8):2727-34. PMC: 6570267. View

Zuckermann E, GLASER G . Urea-induced myoclonic seizures. An experimental study of site of action and mechanism. Arch Neurol. 1972; 27(1):14-28. DOI: 10.1001/archneur.1972.00490130016003. View

Bedard M, Montplaisir J, Godbout R, Lapierre O . Nocturnal gamma-hydroxybutyrate. Effect on periodic leg movements and sleep organization of narcoleptic patients. Clin Neuropharmacol. 1989; 12(1):29-36. View

Swanson P, LUTTRELL C, Magladery J . Myoclonus--a report of 67 cases and review of the literature. Medicine (Baltimore). 1962; 41:339-56. DOI: 10.1097/00005792-196212000-00003. View

Mori S, Ohta Y, Sakamoto T, Nonaka S . Excitability level-setting mechanisms in the pons: their behavioral support in decerebrate, reflex standing and freely moving, intact cats. Brain Dev. 1986; 8(4):408-15. DOI: 10.1016/s0387-7604(86)80062-6. View

Hattori T, Hirayama K, Imai T, Yamada T, Kojima S . Pontine lesion in opsoclonus-myoclonus syndrome shown by MRI. J Neurol Neurosurg Psychiatry. 1988; 51(12):1572-5. PMC: 1032776. DOI: 10.1136/jnnp.51.12.1572. View

Jones B, Beaudet A . Distribution of acetylcholine and catecholamine neurons in the cat brainstem: a choline acetyltransferase and tyrosine hydroxylase immunohistochemical study. J Comp Neurol. 1987; 261(1):15-32. DOI: 10.1002/cne.902610103. View

Bressman S, Fahn S, Eisenberg M, Brin M, Maltese W . Biotin-responsive encephalopathy with myoclonus, ataxia, and seizures. Adv Neurol. 1986; 43:119-25. View

10.

LAPRESLE J . Palatal myoclonus. Adv Neurol. 1986; 43:265-73. View

11.

Becker P, Jamieson A, Brown W . Dopaminergic agents in restless legs syndrome and periodic limb movements of sleep: response and complications of extended treatment in 49 cases. Sleep. 1993; 16(8):713-6. DOI: 10.1093/sleep/16.8.713. View

12.

Pranzatelli M . The neurobiology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol. 1992; 15(3):186-228. DOI: 10.1097/00002826-199206000-00002. View

13.

Geisler P, MEIER-EWERT K, Matsubayshi K . Rapid eye movements, muscle twitches and sawtooth waves in the sleep of narcoleptic patients and controls. Electroencephalogr Clin Neurophysiol. 1987; 67(6):499-507. DOI: 10.1016/0013-4694(87)90051-4. View

14.

Burke W, Ramzan I . Myoclonus in the decerebrate cat produced by gallamine. Brain Res. 1992; 580(1-2):189-96. DOI: 10.1016/0006-8993(92)90944-5. View

15.

Palmer J, Tippett D, Wolf J . Synchronous positive and negative myoclonus due to pontine hemorrhage. Muscle Nerve. 1991; 14(2):124-32. DOI: 10.1002/mus.880140207. View

16.

Hauw J, ESCOUROLLE R, Baulac M, MOREL-MAROGER A, GOULON M, CASTAIGNE P . Postmortem studies on posthypoxic and post-methyl bromide intoxication: case reports. Adv Neurol. 1986; 43:201-14. View

17.

Wiklund L, Leger L, Persson M . Monoamine cell distribution in the cat brain stem. A fluorescence histochemical study with quantification of indolaminergic and locus coeruleus cell groups. J Comp Neurol. 1981; 203(4):613-47. DOI: 10.1002/cne.902030405. View

18.

Lai Y, Clements J, Siegel J . Glutamatergic and cholinergic projections to the pontine inhibitory area identified with horseradish peroxidase retrograde transport and immunohistochemistry. J Comp Neurol. 1993; 336(3):321-30. PMC: 9046457. DOI: 10.1002/cne.903360302. View

19.

Fallon J, Moore R . Catecholamine innervation of the basal forebrain. IV. Topography of the dopamine projection to the basal forebrain and neostriatum. J Comp Neurol. 1978; 180(3):545-80. DOI: 10.1002/cne.901800310. View

20.

DAHLSTROEM A, Fuxe K . EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS. Acta Physiol Scand Suppl. 1964; :SUPPL 232:1-55. View