Role of Transforming Growth Factor-beta in Long-term Synaptic Facilitation in Aplysia

Overview

Journal Science

Specialty Science

Date 1997 Feb 28

PMID 9036859

Citations 65

Authors

F Zhang

S Endo

L J Cleary

A Eskin

J H Byrne

Affiliations

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Abstract

The role of transforming growth factor-beta (TGF-beta) in long-term synaptic facilitation was examined in isolated Aplysia ganglia. Treatment with TGF-beta1 induced long-term facilitation (24 and 48 hours), but not short-term (5 to 15 minutes) or intermediate-term (2 to 4 hours) facilitation. The long-term effects of TGF-beta1 were not additive with those of serotonin. Moreover, serotonin-induced facilitation was blocked by an inhibitor of TGF-beta. Thus, activation of TGF-beta may be part of the cascade of events underlying long-term sensitization, consistent with the hypothesis that signaling molecules that participate in development also have roles in adult neuronal plasticity.

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