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No Evidence for Product Inhibition of the Renin-angiotensinogen Reaction in the Rat

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Journal Circ Res
Date 1977 Oct 1
PMID 902373
Citations 19
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Abstract

The influence of the product of the renin-angiotensinogen reaction, the des-angiotensin I-substrate (des-AI-substrate) on the renin-angiotensinogen reaction has been studied. Des-AI-substrate was prepared from purified rat angiotensinogen by reaction with immobilized renin. The des-AI-substrate had no inhibitory effect on the reaction of partially purified rat renin with rat angiotensinogen at concentrations corresponding to 0.225 or 0.45 micrometer angiotensinogen.

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