Effect of Corticotropin Releasing Factor (CRF) Injected into the Median Eminence on LH Secretion in Male Rats

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1997 Feb 1

PMID 9016842

Citations 3

Authors

J Frias

A Puertas

E Ruiz

E Ortega

Affiliations

Soon will be listed here.

Abstract

We determined the dose-response relationship and examined the time-related effect of CRF (corticotropin releasing factor) injected directly into the Median Eminence (ME) on LH secretion in conscious intact and castrated male rats. Doses of 0.25, 0.75, 1, and 1.5 nmol CRF dissolved in 1 microl of saline (or saline only in the controls) were injected into the ME and blood samples collected 30, 60, 90, and 120 min postinjection to determine by RIA serum LH. CRF at doses of 0.75, 1 and 1.5 nmol significantly decreased serum LH in castrated and intact animals. The lower dose of CRF did not decrease LH in the two groups studied. The results suggest that in males as in females, CRF inhibits by itself LH secretion, at least in part, by a central action in the ME; the inhibitory effect of CRF on LH is similar in castrated and intact males; the dose of 0.25 nmoles of CRF was ineffective in decreasing LH and finally that CRF at ME levels may participate in a variety of stress-related responses, including reproduction inhibition, through LH suppression.

Citing Articles

DHEA, PREG and their sulphate derivatives on plasma and brain after CRH and ACTH administration.

Torres J, Ortega E Neurochem Res. 2003; 28(8):1187-91.

PMID: 12834258 DOI: 10.1023/a:1024276328127.

Effects of CRH and ACTH administration on plasma and brain neurosteroid levels.

Torres J, Ruiz E, Ortega E Neurochem Res. 2001; 26(5):555-8.

PMID: 11513484 DOI: 10.1023/a:1010925331768.

Effect of corticotropin releasing factor injected into the median eminence on growth hormone secretion in male rats.

Frias J, Ruiz E, Ortega E Neurochem Res. 1999; 24(6):715-8.

PMID: 10447453 DOI: 10.1023/a:1020719227235.

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