Precluding Uracil from DNA

Overview

Journal Structure

Publisher Cell Press

Specialties Biochemistry
Biotechnology
Cell Biology
Molecular Biology

Date 1996 Dec 15

PMID 8994964

Citations 6

Authors

D G Vassylyev

K Morikawa

Affiliations

Soon will be listed here.

Abstract

Two enzymes, dUTP pyrophosphatase and uracil-DNA glycosylase, prevent the misincorporation of uracil into the genome in distinct manners. The atomic structures of these proteins complexed with substrate analogs reveal the structural basis for uracil recognition and suggest a novel mechanism of DNA repair.

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