Reduced Ubiquitin-dependent Degradation of C-Jun After Phosphorylation by MAP Kinases

Overview

Journal Science

Specialty Science

Date 1997 Jan 17

PMID 8994040

Citations 138

Authors

A M Musti

M Treier

D Bohmann

Affiliations

Soon will be listed here.

Abstract

The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent control of gene expression.

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