IL-4-induced Immune Deviation As Antigen-specific Therapy for Inflammatory Autoimmune Disease

Overview

Journal Immunol Today

Specialty Allergy & Immunology

Date 1996 May 1

PMID 8991384

Citations 58

Authors

M Rocken

M Racke

E M Shevach

Affiliations

Soon will be listed here.

Abstract

Organ-specific autoimmune diseases are mediated by interferon gamma (IFN-gamma)-producing T helper 1 (Th1) cells. Here, Martin Röcken and colleagues review the experimental basis for an antigen-specific therapeutic approach to inflammatory autoimmune diseases. This strategy involves selective deviation of harmful Th1 responses towards an anti-inflammatory, interleukin 4 (IL-4)-producing Th2 phenotype.

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