Cholecystokinin in Anxiety

Overview

Journal Eur Neuropsychopharmacol

Publisher Elsevier

Specialties Pharmacology
Psychiatry

Date 1996 Nov 1

PMID 8985709

Citations 20

Authors

H J van Megen

H G Westenberg

J A den Boer

R S Kahn

Affiliations

Soon will be listed here.

Abstract

Cholecystokinin (CCK) plays an important role in both the alimentary tract and the central nervous system (CNS). At present it seems to be the most abundant neuropeptide in the CNS. This paper reviews the CCK neuronal system and its interactions with gamma-aminobutyric acid (GABA) and serotonin (5-hydroxytryptamine; 5-HT). In addition, its putative role in anxiety will be discussed on the basis of animal data and studies in healthy volunteers and panic disorder patients. According to these investigations, the CCK4 challenge test fulfills most criteria for an ideal panicogenic agent and evidence has been found that CCKB receptor antagonists might possess anxiolytic properties in man.

Citing Articles

Cholecystokinin-Mediated Neuromodulation of Anxiety and Schizophrenia: A "Dimmer-Switch" Hypothesis.

Ballaz S, Bourin M Curr Neuropharmacol. 2020; 19(7):925-938.

PMID: 33185164 PMC: 8686311. DOI: 10.2174/1570159X18666201113145143.

Blockade of the cholecystokinin CCK-2 receptor prevents the normalization of anxiety levels in the rat.

Ballaz S, Bourin M, Akil H, Watson S Prog Neuropsychopharmacol Biol Psychiatry. 2019; 96:109761.

PMID: 31526831 PMC: 6935156. DOI: 10.1016/j.pnpbp.2019.109761.

Interaction between cholecystokinin and the fibroblast growth factor system in the ventral tegmental area of selectively bred high- and low-responder rats.

Ballaz S, Perez J, Waselus M, Akil H, Watson S Neuroscience. 2013; 255:68-75.

PMID: 24121132 PMC: 3855030. DOI: 10.1016/j.neuroscience.2013.09.063.

The biology of fear- and anxiety-related behaviors.

Steimer T Dialogues Clin Neurosci. 2011; 4(3):231-49.

PMID: 22033741 PMC: 3181681.

cDNA microarray analysis of gene expression in the cerebral cortex and hippocampus of BALB/c mice subjected to chronic mild stress.

Liu Y, Yang N, Zuo P Cell Mol Neurobiol. 2010; 30(7):1035-47.

PMID: 20532976 PMC: 11498782. DOI: 10.1007/s10571-010-9534-8.