The Influence of Food on the Absorption and Metabolism of Drugs: an Update

Overview

Journal Eur J Drug Metab Pharmacokinet

Date 1996 Jul 1

PMID 8980916

Citations 18

Authors

L Williams

D P Hill Jr

J A Davis

D T Lowenthal

Affiliations

Soon will be listed here.

Abstract

Food-drug interactions can lead to a loss of therapeutic efficacy or toxic effects of drug therapy. Generally, the effect of food on drugs results in a reduction in the drug's bioavailability; however, food can also alter drug clearance. The benefits of considering metabolism and pharmacokinetic information in the drug discovery process have been highlighted by Humphrey and Smith (79) and the process of rational drug design should include considerations of the chemistry, pharmacology and pharmacokinetics of the drug (80) and the impact of diet on these parameters.

Citing Articles

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The effect of food on the pharmacokinetics of Sutetinib maleate capsule, an irreversible EGFR tyrosine kinase inhibitor, in healthy Chinese subjects.

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Do dietary interventions exert clinically important effects on the bioavailability of β-lactam antibiotics? A systematic review with meta-analyses.

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Pharmacokinetics and safety of the two oral cefaclor formulations in healthy chinese subjects in the fasting and postprandial states.

Qu X, Deng Q, Li Y, Li P, Liu G, Wang Y Front Pharmacol. 2022; 13:1012294.

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Drug-food Interactions in the Era of Molecular Big Data, Machine Intelligence, and Personalized Health.

Roy R, Marakkar S, Vayalil M, Shahanaz A, Anil A, Kunnathpeedikayil S Recent Adv Food Nutr Agric. 2022; 13(1):27-50.

PMID: 36173075 PMC: 10258917. DOI: 10.2174/2212798412666220620104809.

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