Interaction of Salmonella Typhi Strains with Cultured Human Monocyte-derived Macrophages

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1997 Jan 1

PMID 8975929

Citations 8

Authors

D R Sizemore

E A Elsinghorst

L C Eck

A A Branstrom

D L Hoover

R L Warren

F A Rubin

Affiliations

Soon will be listed here.

Abstract

Human monocyte-derived macrophages (MDM) provided this laboratory with a tool to develop a primary-cell assay for evaluating the relative virulence of newly constructed Salmonella typhi carrier strains. In this study, the interaction with and survival within MDM were compared for delta aroA143-attenuated strains, wild-type virulent strains, and the current oral-vaccine strain, Ty21a.

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